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Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu.
J Xenobiot
January 2025
Laboratory of Toxicology, Department of Pharmacological and Biomolecular Science, University of Milan, Via Balzaretti 9, 20133 Milan, Italy.
Endocrine-disrupting chemicals (EDCs) are natural or synthetic substances that are able to interfere with hormonal systems and alter their physiological signaling. EDCs have been recognized as a public health issue due to their widespread use, environmental persistence and the potential levels of long-term exposure with implications in multiple pathological conditions. Their reported adverse effects pose critical concerns about their use, warranting their strict regulation.
View Article and Find Full Text PDFGeneralizing from qualitative data: a case example using critical realist thematic analysis and mechanism mapping to evaluate a community health worker-led screening program in India.
Implement Sci
December 2024
Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Background: A central goal of implementation science is to generate insights that allow evidence-based practices to be successfully applied across diverse settings. However, challenges often arise in preserving programs' effectiveness outside the context of their intervention development. We propose that qualitative data can inform generalizability via elucidating mechanisms of an intervention.
View Article and Find Full Text PDFT cell dynamics with neoadjuvant immunotherapy in head and neck cancer.
Nat Rev Clin Oncol
December 2024
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Immune-checkpoint inhibitors (ICIs) are being tested as neoadjuvant therapies in various solid tumours, including in patients with head and neck squamous cell carcinoma (HNSCC), with promising results. Key findings thus far include that this approach is well-tolerated with favourable clinical outcomes including promising pathological response rates in initial studies. Pathological responses are likely to be increased by combining other agents with anti-PD-(L)1 antibodies.
View Article and Find Full Text PDFImpact of mixed Staphylococcus aureus-Pseudomonas aeruginosa biofilm on susceptibility to antimicrobial treatments in a 3D in vitro model.
Sci Rep
November 2024
INSERM U1070 "Pharmacology of antimicrobial agents and resistances", University of Poitiers, Pôle Biologie Santé, 1 rue Georges Bonnet, Poitiers, 86022, France.
Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria co-isolated from chronic infected wounds. Their interactions remain unclear but this coexistence is beneficial for both bacteria and may lead to resistance to antimicrobial treatments. Besides, developing an in vitro model where this coexistence is recreated remains challenging, making difficult their study.
View Article and Find Full Text PDFCalcium regulates the physiological and molecular responses of Morus alba roots to cadmium stress.
J Hazard Mater
December 2024
Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, PR China. Electronic address:
Heavy metal cadmium (Cd) is toxic to organisms. Mulberry (Morus alba L.) is a fast-growing perennial that is also an economical Cd phytoremediation material with large biomass.
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