Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0140-6736(70)91306-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide.
Oxid Med Cell Longev
January 2011
University of Belgrade, Institute for Multidisciplinary Research, Department of Biophysics, Belgrade, Serbia.
Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p < 0.001) of the placental catalase (81.
View Article and Find Full Text PDFAnti-thrombic activity of Korean herbal medicine, Dae-Jo-Whan and its herbs.
Vascul Pharmacol
October 2005
Department of Pediatrics, Dongguk University and National Research Laboratory for Glycobiology and Cardiovascular Medical Research Center, Sukjang-Dong 707, Kyungju City, Kyungbuk 780-714, South Korea.
The anti-thrombic properties of the Korean herbal medicine, Dae-Jo-Hwan (DJW), which is consisted of 11 herbs (indicated as concentrations) of Rehmanniae radix 24%, Hominis placenta 5%, Testudinis carapax 9%, Eucommiae cortex 9%, Asparagi radix 9%, Phellodendri cortex 9%, Achyranthis radix 7%, Liriopis tuber 7%, Angelicae sinensis radix 7%, Ginseng radix 6%, and Schizandrae fructus 3%, were investigated. The extracts of DJW and its 11 herbs, except G. radix, A.
View Article and Find Full Text PDFPreparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.
Biochemistry
October 2000
Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099, USA.
Factor Xa plays a critical role in the formation of blood clots. This serine protease catalyzes the conversion of prothrombin to thrombin, the first joint step that links the intrinsic and extrinsic coagulation pathways. There is considerable interest in the development of factor Xa inhibitors for the intervention in thrombic diseases.
View Article and Find Full Text PDFPeptide and metal ion-dependent association of isolated helix-loop-helix calcium binding domains: studies of thrombic fragments of calmodulin.
Protein Sci
May 2000
Department of Biological Sciences, University of Calgary, Alberta, Canada.
Calmodulin (CaM), the ubiquitous, eukaryotic, bilobal calcium-binding regulatory protein, has been cleaved by thrombin to create two fragments. TM1 (1-106) and TM2 (107-148). NMR and CD results indicate that TMI and TM2 can associate in the presence of Ca2+ to form a complex similar to native CaM, even though the cleavage site is not in the linker region between two helix-loop-helix domains, but rather within an alpha-helix.
View Article and Find Full Text PDFSelective anticoagulation with active site blocked factor IXa in synthetic patch vascular repair results in decreased blood loss and operative time.
ASAIO J
January 1998
Department of Surgery, Columbia University College of Physicians & Surgeons, New York, USA.
Heparin has been the mainstay of anti thrombic therapy in arterial repair procedures. With increasing use of synthetic patch angioplasty (polytetrafluoroethylene [PTFE] or Dacron, Medical Products, Flagstaff, AZ) to improve long-term patency and limit aneurysmal dilation, however, the use of heparin has been associated with excessive needle hole bleeding, resulting in time delay in the operating room to achieve hemostasis, as well as clinically significant blood loss. Because of the multiple sites of action of heparin in the coagulation cascade, both intravascular (desired effect) and extravascular (untoward side effect) hemostasis are impaired.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!