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The degradation kinetics of a new cephalosporin derivative (1) in aqueous solution were investigated at 60 degrees, mu = 0.05, at pH 2.0-10.0. The observed degradation rates followed pseudo-first-order kinetics and were influenced significantly by H2O and OH- catalysis. No primary salt effect was observed in the acid region, but a positive salt effect was observed at pH 9.4. A general base catalytic effect by a phosphate buffer species was observed at pH 7-8. The pH-rate profile for I exhibited a degradation minimum at pH 6.05. The Arrhenius activation energies determined at pH 4.0 and 9.4 were 27.2 and 24.5 kcal/mole, respectively. Excellent agreement between the theoretical pH-rate profile and the experimental data supported the hypothesized degradation process. A comparison of I and cefazolin revealed close structural and stability analogies.
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