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A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats.
J Neurosci Methods
January 2021
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. Electronic address:
Background: The ongoing crisis related to non-medical use of opioids makes it of continued importance to understand the risk factors for opioid addiction, the behavioral and neurobiological consequences of opioid exposure and to seek potential avenues for therapy. Pre-clinical rodent models have been critical to advancing understanding of opioid consequences for decades, but have been mostly limited to drug delivery by injection or by oral dosing. Inhalation, a significant route for many human users, has not been as well-established.
View Article and Find Full Text PDFGastric smooth muscle cells manifest an abnormal phenotype in Parkinson's disease rats with gastric dysmotility.
Cell Tissue Res
August 2020
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.
Gastroparesis is a common symptom in Parkinson's disease (PD) and whether any change occurs in gastric smooth muscle cells (SMCs) of PD patients is unclear. We previously reported that rats with bilateral substantia nigra lesions induced by 6-hydroxydopamine (6-OHDA), referred to as 6-OHDA rats, manifest typical gastroparesis. In the present study, we further investigate the underlying mechanism.
View Article and Find Full Text PDFEffects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy.
Epilepsia
May 2000
Comprehensive Epilepsy Program, Department of Neurology, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, Virginia 22908, USA.
Purpose: Circadian regulation via the suprachiasmatic nuclei and rest-activity state may influence expression of limbic seizures.
Methods: Male rats (n = 14) were made epileptic by electrical stimulation of the hippocampus, causing limbic status epilepticus and subsequent seizures. We monitored seizures with intrahippocampal electrodes in 12-12-h light/dark (LD) cycles and in continuous dark (DD).
Phasic instantaneous left ventricular blood velocity was measured by radiotelemetry in 28 subjects with a Doppler ultrasonic flowmeter catheter during atrial pacing and induced A-V block Type I Wenckebach A-V block with conduction ratios of 9:8 or lower generally produced a stepwise reduction of peak left ventricular blood velocity in relation to shortened R-R intervals. Longer Wenckebach periods resulted in little or no blood velocity alteration during 1:1 A-V conduction. Those beats following a blocked atrial depolarization were associated with augmented blood velocities.
View Article and Find Full Text PDFWith the use of the Doppler ultrasonic flowmeter catheter, phasic instantaneous left ventricular blood flow velocity was measured by radiotelemetry in 28 subjects during pacemaker-evoked pulsus alternans. Blood velocity alternation was more manifest at faster pacing rates. Four patients demonstrated diastolic blood velocity alternans at the mitral valve.
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