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Face Boundary Formulation for Harmonic Models: Face Image Resembling.
J Imaging
January 2025
Center for Pattern Recognition and Machine Intelligence, Concordia University, Montreal, QC H3G 1M8, Canada.
This paper is devoted to numerical algorithms based on harmonic transformations with two goals: (1) face boundary formulation by blending techniques based on the known characteristic nodes and (2) some challenging examples of face resembling. The formulation of the face boundary is imperative for face recognition, transformation, and combination. Mapping between the source and target face boundaries with constituent pixels is explored by two approaches: cubic spline interpolation and ordinary differential equation (ODE) using Hermite interpolation.
View Article and Find Full Text PDFPlant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers.
Curr Issues Mol Biol
January 2025
Centro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Determining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expression for all cancer types, we grade human miRNAs by their expression level.
View Article and Find Full Text PDFSelection and Engineering of Novel Brighter Bioluminescent Reporter Gene and Color- Tuning Luciferase for pH-Sensing in Mammalian Cells.
Biosensors (Basel)
January 2025
Laboratory of Biochemistry, Molecular Biology and Bioluminescent Systems Technology, Department of Physics, Chemistry and Mathematics, Federal University of Sao Carlos (UFSCAR), Rodovia João Leme dos Santos, km 110, Sorocaba 18052-780, SP, Brazil.
Firefly luciferases have been extensively used for bioanalytical applications, including their use as bioluminescent reporters, biosensors, and for bioimaging biological and pathological processes. Due to their intrinsic pH- sensitivity, in recent years we have demonstrated that firefly luciferases can also be harnessed as color- tuning sensors of intracellular pH. However, it is known that mammalian cells require temperatures higher than 36 °C, which red-shift the bioluminescence spectra of most firefly luciferases, decreasing their activities and the resolution of ratiometric pH analysis.
View Article and Find Full Text PDFModel Selection from Multiple Model Families in Species Distribution Modeling Using Minimum Message Length.
Entropy (Basel)
December 2024
Department of Data Science and Artificial Intelligence, Faculty of Information Technology, Monash University, Clayton, VIC 3800, Australia.
Species distribution modeling is fundamental to biodiversity, evolution, conservation science, and the study of invasive species. Given environmental data and species distribution data, model selection techniques are frequently used to help identify relevant features. Existing studies aim to find the relevant features by selecting the best models using different criteria, and they deem the predictors in the best models as the relevant features.
View Article and Find Full Text PDFOnonin's Antagonistic Activity towards TRPV1: Insights from Molecular Dynamics and Capsaicin-Evoked Calcium Response in DRG Neurons.
Curr Med Chem
January 2025
Department of Anatomy and Histology, School of Medicine, The University of Jordan, 11942, Amman, Jordan.
Background: The search for effective painkillers has led to intensive research, with a particular focus on the transient receptor potential vanilloid-1 (TRPV1) channel as a possible target.
Methods: One promising candidate is ononin, which is investigated for its binding with TRPV1 through a 200-ns molecular dynamic simulation and analysed via root-meansquare deviation (RMSD), root-mean-square fluctuation (RMSF), hydrogen-bond interactions, radius of gyration (RadGyr), and MM-PBSA energy calculations. The results were further validated experimentally via calcium imaging studies.
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