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A Perspective on Lung Cancer and Lung Microbiome: Insight on Immunity.
Immun Inflamm Dis
February 2025
Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Arak Branch, Arak, Iran.
Background: Although the carcinogenic potential of microbes has long been recognized, their significance may have been underestimated. Currently, the connection between microbiota and cancer is under extensive research. The lung microbiota may serve as a proxy for the state of lung health based on its crucial role in preserving lung hemostasis.
View Article and Find Full Text PDFSARS-CoV-2 surveillance in a hospital and control of an outbreak on a geriatric ward using whole genome sequencing.
Infect Prev Pract
September 2024
SARS-CoV-2 Sequencing Consortium, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Background: During the SARS-CoV-2 pandemic, dominant viral variants were repeatedly replaced by new variants with altered properties, frequently changing the dynamics of the infection event, as well as the effectiveness of vaccines and therapeutics. SARS-CoV-2 variant monitoring by whole genome sequencing was established at the University Medical Center Mainz, Germany to support patient management during the pandemic.
Methods: SARS-CoV-2 RNA samples from the University Medical Center were analysed weekly with whole genome sequencing.
Mpox Virus as a Global Public Health Emergency: A Scoping Review.
Can J Infect Dis Med Microbiol
January 2025
Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Linköping University, Linköping 58183, Sweden.
The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. The virus that was endemic in West and Central Africa has now been reported with chains of global transmission to several countries. A scoping review was carried out from the relevant literature available from PubMed, Scopus and Web of Science.
View Article and Find Full Text PDFZika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting.
Commun Biol
January 2025
Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Transmission of Zika virus (ZIKV) has been reported in 92 countries and the geographical spread of invasive virus-borne vectors has increased in recent years. Arboviruses naturally survive between vertebrate hosts and arthropod vectors. Transmission success requires the mosquito to feed on viraemic hosts.
View Article and Find Full Text PDFThe chiral 5,6-cyclohexane-fused uracil ring-system: A molecular platform with promising activity against SARS-CoV-2.
Eur J Med Chem
January 2025
Department of Food and Drug, University of Parma, Parco Area Delle Scienze 27/A, 43124, Parma, Italy. Electronic address:
The recurrent global exposure to highly challenging viral epidemics, and the still limited spectrum of effective pharmacological options step on the accelerator towards the development of new antiviral medicines. In this work we explored the anti-SARS-CoV-2 potential of a recently launched chiral ring system based on the uracil scaffold fused to carbocycle rings. The asymmetric synthesis of two generations of chiral uracil-based compounds (overall 31 different products), and their in vitro cytotoxicity and antiviral screening against wild-type SARS-CoV-2 in U87.
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