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[A rare cause of multiple cavitary lung lesions].

Pneumologie

December 2024

Medizinische Klinik 5 (Pneumologie), Klinikum Fulda gAG, Campus Fulda, Universitätsmedizin Marburg, Fulda, Deutschland.

We report on a 32-year-old woman with multiple, progressive cavitary lung lesions. Lung cavities may occur in the context of various diseases and, thus, represent a huge diagnostic challenge. The spectrum of diseases comprises infections, systemic autoimmune rheumatic diseases, and malignancies.

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Granulomatosis With Polyangiitis Misdiagnosed as Tuberculosis: A Case Report.

Cureus

October 2024

Internal Medicine, Unidade Local de Saude do Alto Minho, Viana do Castelo, PRT.

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a rare autoimmune disorder characterized by necrotizing vasculitis affecting small to medium-sized vessels. This condition most commonly affects the lungs, kidneys, and upper respiratory tract. Early recognition and treatment are critical to prevent severe complications and improve prognosis.

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This case represents the first diagnosis of pachymeningitis due to granulomatosis with polyangiitis (GPA) in an elderly Iranian man who initially presented with persistent daily headaches. PCR tests of cerebrospinal fluid for tuberculosis, brucellosis, and fungal infections all yielded negative results. Given the pachymeningitis pattern observed on brain MRI and the absence of infectious and lymphoma diseases, along with positive anti-PR3 and proteinuria (793 mg in a 24-h urine sample), a diagnosis of GPA was established.

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Sarcoidosis is a systemic granulomatosis of unknown etiology. Mediastinal lymph node and pulmonary involvement are the most characteristic manifestations. However, bone involvement is rare during sarcoidosis.

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A rare case of Whipple disease presenting as a hydrosalpinx and granulomatous peritonitis.

J Infect Dev Ctries

August 2024

Department for Gastroenterology, Military Medical Academy, Belgrade, Serbia.

Article Synopsis
  • Whipple disease, caused by the bacterium Tropheryma whipplei, is a rare infection that primarily impacts the gastrointestinal and musculoskeletal systems but can also affect the heart, brain, and lungs, making diagnosis difficult due to varied symptoms.
  • A case study of a young woman revealed miliary lesions in the pelvis during laparoscopy, initially leading to a diagnosis of granulomatous salpingitis and peritonitis, but ultimately, Tropheryma whipplei was identified as the cause.
  • Timely and appropriate antibiotic treatment is crucial for a positive outcome in Whipple disease, emphasizing the need for increased awareness among healthcare professionals.
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