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Technology of Combined Identification of Macrophages and Collagen Fibers in Liver Samples.
Sovrem Tekhnologii Med
December 2024
MD, DSc, Professor of the Russian Academy of Sciences, Head of the Laboratory of Functional Morphology of Central and Peripheral Nervous System; Head of the Department of General and Special Morphology; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia.
Unlabelled: The importance of identifying pathological changes in the liver both in fundamental researches and in diagnostic practice dictates the necessity to have a convenient method of assessing functional condition of resident macrophages and connective tissue fibers. is to assess the technology of combined histo-immunohistochemical detection of collagen fibers of connective tissue and resident liver macrophages using aniline blue histological stain and available antibodies to the microglial marker, the Iba-1 protein.
Materials And Methods: Liver samples from adult rats (n=6) have been used in the study.
Aim - to improve the methodology for collecting material from lesions of the oral mucosa for exfoliative cytological examination. A group of patients diagnosed with B37.0 Candida stomatitis was examined.
View Article and Find Full Text PDFAn and investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature.
Ann Med
December 2023
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Several neurodegenerative conditions are associated with a common histopathology within neurons of the central nervous system, consisting of the deposition of cytoplasmic inclusions of TAR DNA-binding protein 43 (TDP-43). Such inclusions have variably been described as morphologically and molecularly ordered aggregates having amyloid properties, as filaments without the cross-β-structure and dye binding specific for amyloid, or as amorphous aggregates with no defined structure and fibrillar morphology. Here we have expressed human full-length TDP-43 in neuroblastoma x spinal cord 34 (NSC-34) cells to investigate the morphological, structural, and tinctorial properties of TDP-43 inclusions .
View Article and Find Full Text PDFPecularities of Candida yeast identification by mass spectrometric analysis (MALDI-ToF MS).
Klin Lab Diagn
April 2022
To carry the comparative analysis of sample preparation methods for the most effective identification of Candida yeast by mass spectrometric analysis. 265 strains of yeast and yeast-like fungi isolated from the sputum of patients with pneumonia were investigated. The selected strains were identified by conventional methods (cultural, morphological, tinctorial, enzymatic properties) and MALDI-ToF MS using the Autoflex speed III Bruker Daltonics mass spectrometer (Germany) and Flex Control software.
View Article and Find Full Text PDFOrigin, toxicity and characteristics of two amyloid oligomer polymorphs.
RSC Chem Biol
December 2021
Dept. of Physics, University of South Florida Tampa FL 33620 USA
There is compelling evidence that small oligomeric aggregates, emerging during the assembly of amyloid fibrils and plaques, are important molecular pathogens in many amyloid diseases. While significant progress has been made in revealing the mechanisms underlying fibril growth, understanding how amyloid oligomers fit into the fibril assembly process, and how they contribute to the pathogenesis of amyloid diseases, has remained elusive. Commonly, amyloid oligomers are considered to be metastable, early-stage precursors to fibril formation that are either on- or off-pathway from fibril growth.
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