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Potential risk factors of protein aggregation in syringe handling during antibody drug dilution for intravenous administration.
J Pharm Sci
January 2025
Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Protein aggregation, a major concern in biopharmaceutical quality control, can be accelerated by various stresses during clinical handling. This study investigated potential aggregation risk factors during dilution process with syringe handling for intravenous administration. Using γ-globulin and IgG solutions as surrogate models of antibody therapeutics, we examined the effects of high sliding speeds and piston operations of the syringe on protein aggregation during saline dilution.
View Article and Find Full Text PDFEnzymic Activity, Metabolites, and Hematological Responses Changes of Clinical Healthy High-Risk Beef Calves During Their First 56-Days from Arrival.
Animals (Basel)
January 2025
Unidad Académica de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Zacatecas, General Enrique Estrada 98500, Mexico.
The objective of this study was to evaluate the changes in enzymic activity, metabolites, and hematological responses during the first 56-d of arrival of newly received calves, which were qualified at reception as high-risk but diagnosed as clinically healthy. A total of 320 blood samples were taken from 64 crossbred bull calves (average initial body weight = 148.3 ± 1.
View Article and Find Full Text PDFChia () Seed Oil Modulates the Haemato-Immunological Response, Antioxidative Status and Cytokine Gene Expression of Tropical Freshwater Teleost, .
Biology (Basel)
January 2025
ICAR-Indian Institute of Agricultural Biotechnology, Ranchi 834010, India.
The present investigation attempts to evaluate the impact of the dietary inclusion of chia () seed oil (CSO) on the indices of haemato-immunology, metabolic enzymes, and expression of immune-responsive cytokine genes in (rohu) fingerlings. The responses were observed in a 60-day feeding trial, set up with a total of 180 rohu fingerlings (19.74 ± 0.
View Article and Find Full Text PDFA longitudinal study on the detection of anti-Leishmania antibodies in a captive European mink (Mustela lutreola) population and their correlation with serum protein electrophoresis.
Res Vet Sci
January 2025
Animal Pathology Department, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain; Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain. Electronic address:
Leishmaniosis, caused by Leishmania infantum and transmitted by sand flies, is a significant zoonotic disease. Dogs are primary reservoirs, but other domestic animals, such as cats and ferrets, and wild species, including Eurasian otters and European mink, can be hosts. This study focused on European mink, a critically endangered species, investigating the seroprevalence of L.
View Article and Find Full Text PDFQuantification of Albumin and ɣ-Globulin Concentrations by Multivariate Regression Based on Admittance Relaxation Time Distribution (mrARTD).
Biomed Phys Eng Express
January 2025
Dept. Mechanical Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, Chiba, 263-8522, JAPAN.
Albumin and γ-globulin concentrations in subcutaneous adipose tissues (SAT) have been quantified by multivariate regression based on admittance relaxation time distribution (mraRTD) under the fluctuated background of sodium electrolyte concentration. The mraRTD formulates P = Ac + Ξ (P: peak matrix of distribution function magnitude ɣP and frequency τP, c: concentration matrix of albumin cAlb, γ-globulin Gloc, and sodium electrolyte Nac, A: coefficient matrix of a multivariate regression model, and Ξ: error matrix). The mraRTD is implemented by two processes which are: 1) the training process of A through the maximum likelihood estimation of P and 2) the quantification process of cAlb, Gloc, and Nac through the model prediction.
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