Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A Model of Zymogen Factor XII: Insights into Protease Activation.
Blood Adv
January 2025
Vanderbilt University Medical Center, Nashville, Tennessee, United States.
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to regulation of blood vessel tone and permeability. Plasma FXII is normally in a "closed" conformation that limits activation by PKa.
View Article and Find Full Text PDFNatural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment.
Med Oncol
January 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Bladder cancer (BC) is a major global health issue with a high recurrence rate and limited effective treatments. Over the past few years, it has become evident that miRNAs play a role in the carcinogenesis process, particularly in regulating genes that promote cancer cell proliferation and invasion. This review focuses on the extent to which natural products can act as potential miRNA modulators for the management of bladder cancer.
View Article and Find Full Text PDFLow temperature thermal RAFT depolymerization: the effect of Z-group substituents on molecular weight control and yield.
Chem Sci
January 2025
Laboratory of Polymeric Materials, Department of Materials, ETH Zurich Vladimir Prelog Weg 5 8093 Zurich Switzerland
The labile end-groups inherent to many controlled radical polymerization methodologies, including atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain-transfer (RAFT) polymerization, can trigger the efficient chemical recycling of polymethacrylates yielding high percentages of pristine monomer. Yet, current thermal solution ATRP and RAFT depolymerization strategies require relatively high temperatures ( 120-170 °C) to proceed, with slower depolymerization rates, and moderate yields often reported under milder reaction conditions ( lower temperatures). In this work, we seek to promote the low temperature RAFT depolymerization of polymethacrylates regulating the Z-group substitution of dithiobenzoate.
View Article and Find Full Text PDFOptimizing woodcutting with zirconia-toughened alumina: Processing, performance, and industrial insights.
Heliyon
January 2025
Swiss Federal Laboratories for Materials Science and Technology (Empa), Laboratory for High Performance Ceramics, 8600, Dübendorf, CH, Switzerland.
Since the 1950s, the woodcutting industry has relied heavily on tungsten carbide (WC) cutting tools to overcome the challenges posed by the complex structure of wood, including hard knots and abrasive elements such as sand and tannic acids. These demands require cutting tools with superior thermal conductivity and mechanical properties. However, the rising cost of WC materials has prompted the search for alternative solutions.
View Article and Find Full Text PDFMultifaceted impacts of double-aging neighborhood's built environments on SAIP: a deep dive into Chinese rapidly aging urban society.
Front Public Health
January 2025
Department of Geography and Spatial Information Techniques, Ningbo University, Ningbo, China.
Introduction: The healthy aging of older adults in dual-older adult communities is influenced by multiple factors, and understanding its underlying mechanisms can promote healthy aging among the older adults in a wide range of developing countries. This comprehensive study delves into the intricate interplay between multifaceted built environmental factors, and their direct and indirect effects on the successful AIP residing in double-aging neighborhoods.
Methods: Applying a series of HLM, the research meticulously explores the intricate links between SAIP and multi-scale aging spaces, including home space, community social participation, and built environments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!