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Superstable lipid vacuoles endow cartilage with its shape and biomechanics.
Science
January 2025
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.
Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Background: Emerging evidence strongly suggests that terminally differentiated neurons in the brain have the potential to undergo a cell cycle-like process during neuronal aging and in the presence of certain diseases. However, due to their infrequent occurrence and unpredictable distribution within the brain, the molecular characteristics and specific variations associated with these cells in different diseases are still not well understood.
Method: By taking advantage of the wealth of human brain single-nucleus RNA sequencing (snRNA-seq) datasets available in public repositories, we developed an analytical pipeline that facilitates the identification and characterization of cell cycle gene re-expressing neurons to address these questions.
Background: Treatment with the RXR-specific agonist Bexarotene exerts neuroprotective effects in Alzheimer's disease (AD) mouse models by improving cognition and increasing Aβ clearance. At the transcriptional level, ligand-activated RXR receptors regulate gene networks linked to neural development, neuroinflammation, and metabolism. This study aimed to reveal the association between changes in chromatin architecture and transcriptional activity in the brain of Bexarotene-treated APP/PS1 mice.
View Article and Find Full Text PDFThe landscape of GPCR in the skin epidermal stem cells: From the basic to the clinical.
Sheng Li Xue Bao
December 2024
Skin Disease Research Institute, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310058, China.
Skin, as the body's largest organ, acts as the primary defense mechanism against infection and injury. The maintenance of skin health heavily relies on the regulation of epidermal stem cells, crucial for ensuring epidermal homeostasis, hair regeneration, and the repair of epidermal injuries. Recent studies have placed a growing emphasis on G protein-coupled receptor (GPCR) in the context of understanding epidermal stem cells, uncovering its significant role in determining their fate.
View Article and Find Full Text PDFModulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC.
J Transl Med
January 2025
Department of General Surgery of Otorhinolaryngology Head and Neck, The Sixth Affiliated Hospital, Sun Yat-Sen University, No.26, Erheng Road, Yuancun, Tianhe District, Guangzhou, 510655, China.
Purpose: Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on the context, TAMs can either suppress tumor progression and weaken drug sensitivity or facilitate tumor growth and drive therapeutic resistance. This study explores whether targeting TAMs can suppress the progression of head and neck squamous cell carcinoma (HNSCC) and improve the efficacy of chemotherapy.
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