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Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma.
Mol Cell Biol
December 2024
Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
In esophageal squamous cell carcinoma, genetic activation of NRF2 increases resistance to chemotherapy and radiotherapy, which results in a significantly worse prognosis for patients. Therefore NRF2-activated cancers create an urgent clinical need to identify new therapeutic options. In this context, we previously identified the geldanamycin family of HSP90 inhibitors, which includes 17DMAG, to be synthetic lethal with NRF2 activity.
View Article and Find Full Text PDFPrognostic impact of preoperative osteosarcopenia on esophageal cancer surgery outcomes: a retrospective analysis.
Esophagus
January 2025
Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City, Kagoshima, 890-8520, Japan.
Background: Osteosarcopenia, recognized as a consequence of aging, has garnered attention as a prognostic marker in recent years; however, its clinical significance in esophageal cancer remains uncertain. This study aimed to investigate the impact of osteosarcopenia on esophageal cancer surgery outcomes.
Methods: This retrospective study included patients with advanced esophageal cancer who underwent surgical resection between 2018 and 2021.
Comparison of machine learning methods for Predicting 3-Year survival in elderly esophageal squamous cancer patients based on oxidative stress.
BMC Cancer
November 2024
Department of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
Article Synopsis
- This study investigates the connection between oxidative stress and the survival prognosis of elderly patients with esophageal squamous cancer (ESCC), utilizing machine learning models due to a lack of existing research in this area.
- The researchers included elderly ESCC patients who underwent surgery from 2013 to 2020 and analyzed data through Cox regression, ultimately developing an oxidative stress score (OSS) to predict 3-year overall survival rates.
- Among the 485 patients analyzed, key factors influencing survival were identified, and the random forest machine-learning model showed the best predictive performance for survival outcomes in the training cohort.
Synthesis, characterization, antiproliferative activity and DNA binding calculation of substituted-phenyl-terpyridine copper(II) nitrate complexes.
J Inorg Biochem
October 2023
School of Chemistry and Chemical Engineering, Guangxi University, 530004 Nanning, Guangxi, People's Republic of China. Electronic address:
Ten 4'- (R-phenyl) -2,2': 6', 2' - terpyridine ligands (R = hydrogen (L1), hydroxyl (L2), methoxyl (L3), methylsulfonyl (L4), methyl (L5), phenyl (L6), fluoro (L7), chloro (L8), bromo (L9), and iodo (L10)) were synthesized. The reaction of these ligands with copper(II) nitrate led to complexes 1-10. The characterization of 1-10 was carried out by means of mass spectrometry, elemental analysis, infrared spectroscopy and X-ray single crystal diffraction.
View Article and Find Full Text PDFEsophageal speech training system and needs for esophageal speech training in a laryngectomy patient association in Japan.
Jpn J Compr Rehabil Sci
July 2024
School of Nursing & Health, Aichi Prefectural University, Nagoya, Aichi, Japan.
Unlabelled: Watanabe N, Kamakura Y, Fukada J. Esophageal speech training system and needs for esophageal speech training in a laryngectomy patient association in Japan. Jpn J Compr Rehabil Sci 2024; 15: 17-26.
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