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Conversion therapy for unresectable intrahepatic cholangiocarcinoma using gemcitabine plus S-1 combined with PD-1 inhibitors: a case report.
Front Oncol
January 2025
Department of Hepatopancreatobiliary Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor of the liver and gallbladder, which is usually diagnosed at an advanced stage and the opportunity for surgery is lost. Therefore, conversion therapy is important to convert the iCCA into a resectable state. In recent years, the conversion protocol of immuno-chemotherapy has been applied for advanced liver cancer.
View Article and Find Full Text PDFNutrition users' guides: RCTs part 1 - structured guide for assessing risk of bias in randomised controlled trials that address therapy or prevention questions.
BMJ Nutr Prev Health
August 2024
Department of Nutrition, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA.
The purpose of this article, part 1 of 2 on randomised controlled trials (RCTs), is to provide readers (eg, clinicians, patients, health service and policy decision-makers) of the nutrition literature structured guidance on interpreting RCTs. Evaluation of a given RCT involves several considerations, including the potential for risk of bias, the assessment of estimates of effect and their corresponding precision, and the applicability of the evidence to one's patient. Risk of bias refers to flaws in the design or conduct of a study that may lead to a deviation from measuring the underlying true effect of an intervention.
View Article and Find Full Text PDFCircumstantial risk factors for death after intensive care unit-to-unit inter-hospital transfer-a Swedish registry study.
Scand J Trauma Resusc Emerg Med
January 2025
Anaesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, 715 85, Uppsala, Sweden.
Background: Unit-to-unit transfer of critically ill patients infers hazards that may cause adverse events. Circumstantial factors associated with mortality after intensive care include days in the ICU, night-time or weekend discharge and capacity transfer as compared to other reasons for transfer. Distance travelled may also constitute an indirect risk.
View Article and Find Full Text PDFAlterations in fecal bacteriome virome interplay and microbiota-derived dysfunction in patients with schizophrenia.
Transl Psychiatry
January 2025
Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Rising studies have consistently reported gut bacteriome alterations in schizophrenia (SCZ). However, little is known about the role of the gut virome on shaping the gut bacteriome in SCZ. Here in, we sequenced the fecal virome, bacteriome, and host peripheral metabolome in 49 SCZ patients and 49 health controls (HCs).
View Article and Find Full Text PDFBiodegradable fishing gears: A potential solution to ghost fishing and marine plastic pollution.
Mar Pollut Bull
January 2025
UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Fishing gears are conventionally made from non-biodegradable materials including polyamide (PA). When lost in the ocean, these gears have long-lasting impacts, including marine littering, microplastics production, leaching of chemicals, and an extended period of ghost fishing due to its durability. The use of biodegradable co-polyester material such as polybutylene succinate co-adipate-co-terephthalate (PBSAT) and polybutylene succinate-co-butylene adipate (PBSA) as fishing gear materials have been considered as a potential solution to reduce the associated impact.
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