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Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome.
Biomedicines
January 2025
Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 77515 Olomouc, Czech Republic.
Hypertriglyceridemia has serious health risks such as cardiovascular disease, type 2 diabetes mellitus, nephropathy, and others. Fenofibrate is an effective hypolipidemic drug, but its benefits for ameliorating disorders associated with hypertriglyceridemia failed to be proven in clinical trials. To search for possible causes of this situation and possibilities of their favorable influence, we tested the effect of FF monotherapy and the combination of fenofibrate with silymarin on metabolic disorders in a unique model of hereditary hypertriglyceridemic rats (HHTg).
View Article and Find Full Text PDFHypertriglyceridemia and younger age are associated with effectiveness of growth hormone therapy on hepatic steatosis.
Endocr J
January 2025
Department of Diabetes, Endocrinology and Metabolism, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.
Adult growth hormone deficiency (AGHD) is often accompanied with metabolic dysfunction-associated steatotic liver disease (MASLD). Although some studies reported that MASLD is ameliorated by growth hormone replacement therapy (GHRT), the characteristics of AGHD that are associated with an improvement of hepatic steatosis by GHRT remain unknown. We aimed to investigate whether GHRT affects hepatic lipid accumulation as well as biochemical parameters, and investigated the association between these parameters (UMIN000044989).
View Article and Find Full Text PDFWater Extract of Djulis Husk Exerts Protective Effect Against Metabolic Syndrome.
Prev Nutr Food Sci
December 2024
Department of Food Science, National Ilan University, Yilan County 260007, Taiwan.
Djulis ( Koidz.) possesses various biological activities, including anti-oxidant, anti-hyperglycemic, anti-aging and hepatoprotective properties. Although djulis husk is typically considered agricultural waste, there is value in exploring ways to utilize it effectively.
View Article and Find Full Text PDFFatal visceral disseminated varicella zoster virus infection during initial remission induction therapy in a patient with lupus nephritis: a case report and review of the literature.
CEN Case Rep
December 2024
Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Article Synopsis
- The case discusses a 36-year-old man who developed a severe visceral disseminated varicella zoster virus (VZV) infection after starting immunosuppressive therapy for lupus nephritis, leading to a rapid decline in health and multiple organ failure.
- Key symptoms included severe abdominal pain, blistering rashes, hyperferritinemia, and laboratory signs indicating hemophagocytic lymphohistiocytosis (HLH), ultimately resulting in the patient's death.
- This case highlights the rare but critical complication of VZV infections in patients receiving specific immunosuppressive treatments, stressing the importance of early diagnosis through VZV-DNA testing.
Pemafibrate for treating MASLD complicated by hypertriglyceridaemia: a multicentre, open-label, randomised controlled trial study protocol.
BMJ Open
November 2024
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Kanagawa, Japan
Introduction: Non-alcoholic fatty liver disease, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a phenotype of the metabolic syndrome in the liver and is clearly associated with metabolic abnormalities such as hyperglycaemia and dyslipidaemia. Although the prevalence of MASLD is increasing worldwide, there is currently no consensus on the efficacy and safety of the drugs used to treat MASLD/metabolic dysfunction-associated steatohepatitis (MASH). Pemafibrate, a selective peroxisome proliferator-activated receptor alpha modulator, was designed to have higher peroxisome proliferator-activated receptor alfa (PPARα) agonist activity and selectivity than existing PPARα agonists, and in development trials, without increasing creatinine levels, lipid parameters and alanine aminotransferase (ALT) were significantly improved.
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