[A case of IgD-myeloma].

Nihon Ketsueki Gakkai Zasshi

Published: April 1968

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Introduction: Immunoglobulin D (IgD) myeloma is a rare subtype often described as aggressive with advanced disease at diagnosis. Primary renal involvement is seen in scarce cases.

Observation: This case features a 55-year-old man with IgD lambda myeloma presenting severe renal failure at diagnosis.

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[IgD multiple myeloma mimicking free light chain myeloma complicated by factor X deficiency: a case report].

Pan Afr Med J

July 2022

Service d´Hématologie Clinique, Centre Hospitalier de Versailles André Mignot, Faculté de Médecine Xavier Bichat, Université Paris Diderot, Paris, France.

Article Synopsis
  • IgD myeloma is a rare type of blood cancer that often has serious symptoms, making it challenging to differentiate from other forms of myeloma.
  • A case study of a 72-year-old woman highlighted her severe bone pain, bruising, and kidney failure, leading to the diagnosis of IgD lambda myeloma stage IIIb.
  • The patient responded well to a combination of new treatments, including a proteasome inhibitor and stem cell transplant, which improved her prognosis.
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Immunoglobulin D-λ/λ biclonal multiple myeloma: A case report.

World J Clin Cases

April 2021

Department of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China.

Background: Immunoglobulin D (IgD) multiple myeloma (MM) is a rare subtype of MM and commonly occurs in younger subjects but at a later stage of the International Staging System (ISS) when admitted. As a special type of IgD myeloma, IgD-λ/λ biclonal MM is rarer. Its serum protein electrophoresis and serum immuno-fixation electrophoresis (IFE) might find no anomalies even if the bone marrow (BM) examination is performed.

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Light chain deposition disease involving kidney and liver in a patient with IgD myeloma.

BMC Nephrol

January 2021

Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, 929 Higashi-chou, Kamogawa-shi, Chiba, 296-8601, Japan.

Background: IgD multiple myeloma (MM) is a rare subtype of MM and light chain deposition disease (LCDD) outside the kidney is also a rare and has scarcely been reported. We report herein the details of the first reported case of LCDD involving the kidney and liver co-occurring with IgD myeloma.

Case Presentation: A 66-year-old female with IgD MM presented with rapidly progressive acute renal failure, ascites and pleural effusion.

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Multiple myeloma is a haematological malignancy with clonal plasma cell proliferation and production of monoclonal immunoglobulins. Its neurological complications are relatively common, caused by both the disease and the treatment. Neurologists should therefore be familiar with its neurological manifestations and complications.

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