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Innovative Biocompatible Blend Scaffold of Poly(hydroxybutyrate-co-hydroxyvalerate) and Poly(ε-caprolactone) for Bone Tissue Engineering: In Vitro and In Vivo Evaluation.
Polymers (Basel)
October 2024
Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), São Bernardo do Campo 09606-070, Brazil.
This study evaluated the biocompatibility of dense and porous forms of Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), Poly(ε-caprolactone) (PCL), and their 75/25 blend for bone tissue engineering applications. The biomaterials were characterized morphologically using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and the thickness and porosity of the scaffolds were determined. Functional assessments of mesenchymal stem cells (MSCs) included the MTT assay, alkaline phosphatase (ALP) production, and morphological and cytochemical analyses.
View Article and Find Full Text PDFMorphological and cytochemical characterization of the peripheral blood cells in .
Heliyon
September 2024
Lab of Pathology and Immunology of Aquatic Animals, Jiangsu Ocean University, Lianyungang, 222005, China.
The flounder () is a highly nutritious, cultured bony fish with a high economic value. The health of the fish is closely related to its blood cells, which are critical for oxygen transport, natural defense, and immunity. The microstructures, classification, counting and size of peripheral blood cells in .
View Article and Find Full Text PDFAdrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus.
J Pineal Res
August 2024
Institute for Anatomy II, Goethe University Frankfurt, Frankfurt, Germany.
Article Synopsis
- The suprachiasmatic nucleus (SCN) in the hypothalamus is the central control hub for circadian rhythms in mammals, producing various neurotransmitters.
- Researchers confirmed the presence of β-adrenergic receptors in the SCN and examined their effects on energy signaling through cAMP-regulated elements.
- The study's findings suggest that stress-related increases in adrenaline can impact circadian functions and may help explain side effects of β-blockers used for hypertension.
Cytochemical localization and synthesis mechanism of the glucomannan in pseudobulbs of Reichb. f.
Hortic Res
May 2024
Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.
The dried pseudobulbs of , an important traditional Chinese medicine named , have an extraordinary polysaccharide content and excellent prospects for medicinal effects. However, the distribution and molecular mechanism underlying biosynthesis are poorly understood. In this study, chemical and immunologic analyses were performed in representative tissues of , and the results showed that what are conventionally termed polysaccharides (BSPs) are water-soluble polysaccharides deposited only in pseudobulbs.
View Article and Find Full Text PDFClinical and histopathological spectrum of cranial small round cell tumors: An experience from a tertiary care center.
J Cancer Res Ther
January 2024
Department of Neurosurgery, Vardhman Mahavir Medical College and Safdarjung Hospital New Delhi, India.
Background: Small round cell tumors (SRCTs) are a group of malignant neoplasms with minimal or no differentiation, characterized by the presence of round cells with high nuclear-cytoplasmic ratio. Although SRCTs can occur in any part of the body, involvement of central nervous system (CNS) is uncommon.
Aim: We aimed to study the clinicopathological spectrum of cranial SRCT diagnosed in our institute over a period of four years (2016-2019).
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