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Analysis of Measles and Rubella Immunoglobulin G Titers in COVID-19 Patients.
Risk Manag Healthc Policy
November 2024
Department of Family Medicine, Samsun University Faculty of Medicine, Samsun, Turkey.
Background: The objective of this study is to compare the measles immunoglobulin G (IgG) and rubella IgG levels in patient groups with mild and severe COVID-19 disease and reveal the possible relationship.
Methods: This study was conducted among COVID-19-confirmed patients over 18, under 65 years of age. This study involved 75 participants- divided into two groups.
Evaluation of the focus reduction neutralization and ELISA tests compared to the plaque reduction neutralization test for the detection of antibodies against measles virus.
Biologicals
November 2024
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Article Synopsis
- Measles, caused by the measles virus, remains a global health challenge despite the availability of an effective vaccine, with a need for better methods to assess community immunity.* -
- The enzyme-linked immunosorbent assay (ELISA) is the standard immunity test but often fails to detect low antibody levels, while the more accurate plaque reduction neutralization test (PRNT) is impractical for regular use.* -
- This study validated the focus reduction neutralization test (FRNT) as a reliable alternative to PRNT, demonstrating that FRNT provides similar sensitivity and perfect correlation in identifying protective antibodies compared to PRNT.*
Differential diagnosis on measles and rubella discarded cases highlights a sharp increase in parvovirus B19 infections in Milan, Northern Italy, in the first months of 2024.
J Med Virol
September 2024
Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
In line with European trends, since 2023 Lombardy (Northern Italy) is experiencing a resurgence of measles and an increased number of reported cases of fever and rash. Measles discarded cases observed in our region within the context of measles and rubella surveillance from the first few months of 2024 (N = 30) were investigated for parvovirus B19 (B19V) and other rash-associated viruses. Thirteen cases tested positive for B19V DNA, representing a significant increase from previous years (on average 3 cases per year, p < 0.
View Article and Find Full Text PDFAssociation Between Clinical Severity, Neuroimaging, and Electroencephalographic Findings in Children with Subacute Sclerosing Panencephalitis.
J Child Neurol
August 2024
Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Background: Children diagnosed with subacute sclerosing panencephalitis (SSPE) display a range of neuroimaging abnormalities during different stages of the disease, but their exact clinical significance remains unclear.
Methods: In this retrospective cohort study, our objective was to examine magnetic resonance imaging (MRI) abnormalities in the brains of patients aged 18 years or younger with subacute sclerosing panencephalitis. We aimed to correlate these MRI abnormalities with clinical severity, sociodemographic variables, electroencephalographic (EEG) abnormalities, and cerebrospinal anti-measles antibody titers.
Indocyanine green angiography reveals choroidal hypoperfusion in subacute sclerosing panencephalitis (SSPE).
Eur J Ophthalmol
November 2024
Uvea Services, Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India.
We report the choroidal findings on indocyanine green angiography (ICGA) in two cases of subacute sclerosing panencephalitis (SSPE). The two immunocompetent patients (31-year-old and 30-year-old Asian Indian males) presented with acute-onset rapidly progressing vision loss with findings of necrotizing retinitis involving the central macula. Both patients tested negative for serological evidence of herpes or varicella, and toxoplasma antibodies.
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