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Abdominal and intra-abdominal fibromatoses: Outcomes over time.
Am J Clin Pathol
January 2025
Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, FL, US.
Objectives: Abdominal wall and intra-abdominal fibromatoses are locally aggressive, nonmetastasizing neoplasms. Surgery has been the mainstay of local control, but new forms of therapy have been developed that may influence the clinical course and morbidity. We studied the clinical features and outcomes of patients with abdominal and intra-abdominal fibromatoses over time.
View Article and Find Full Text PDFEnhancing equity in academic surgery promotion practices.
Surgery
January 2025
Section of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Chicago, Pritzker School of Medicine, IL. Electronic address:
Background: Black, Indigenous, People of Color (BIPOC) in medicine and women faculty have lower 10-year promotion rates than their White and male peers, despite controlling for productivity metrics. Promotion standards vary across institutions, but there is likely a common need to improve transparency and consistency while mitigating bias, inequity, and the harm of additional equity work that is commonly expected of Black, Indigenous, People of Color and women faculty (the so-called minority tax).
Methods: A promotion advisory committee consisting of clinical and research faculty at all ranks specified expectations for a faculty member at the associate or full professor ranks, with 10-15 examples given for each "mission" (clinical, research, and education).
Prioritizing cases from a multi-institutional cohort for a dataset of pathologist annotations.
J Pathol Inform
January 2025
U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Imaging, Diagnostics, and Software Reliability, Silver Spring, MD, United States of America.
Objective: With the increasing energy surrounding the development of artificial intelligence and machine learning (AI/ML) models, the use of the same external validation dataset by various developers allows for a direct comparison of model performance. Through our High Throughput Truthing project, we are creating a validation dataset for AI/ML models trained in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple negative breast cancer (TNBC).
Materials And Methods: We obtained clinical metadata for hematoxylin and eosin-stained glass slides and corresponding scanned whole slide images (WSIs) of TNBC core biopsies from two US academic medical centers.
Fluorescence confocal microscopy for margin assessment in prostatectomy: IP8-FLUORESCE study protocol.
BJU Int
November 2024
Imperial Prostate, Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Article Synopsis
- Radical prostatectomy (RP) is a key surgical treatment for prostate cancer, but assessing surgical margins during the procedure is difficult and costly, making fluorescence confocal microscopy (FCM) a potential solution.
- The IP8-FLUORESCE study is a multicentre, prospective study that investigates the accuracy of digital FCM in identifying prostate cancer at surgical margins, comparing it to traditional histopathology methods.
- The study will involve 153 patients undergoing robot-assisted RP, using FCM on prostate specimens immediately after surgery, with results evaluated by blinded uro-pathologists for accuracy in detecting cancer presence at the margins.
Analyzing 3D facial morphology: Insights from a comparative European and South African study on population affinity, sex, age, and allometry.
Forensic Sci Int
December 2024
University of Pretoria, Department of Anatomy, Faculty of Health Sciences, Tswelopele Building, Private Bag X323, Prinshof 349-Jr, Pretoria 0084, South Africa. Electronic address:
Variable growth patterns and multifactorial mechanisms cause variation in facial shape. These differences in facial morphology pose challenges for craniofacial reconstruction. Three-dimensional (3D) imaging modalities are a valuable resource for examining these variations.
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