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http://dx.doi.org/10.1620/tjem.95.127 | DOI Listing |
Sci Rep
November 2024
Jiangxi Key Laboratory of Crop Growth and Development Regulation, College of Life Sciences and Resources and Environment, Yichun University, Yichun, 336000, China.
Fumarylacetoacetate hydrolase (FAH) catalyzes the final step of the tyrosine degradation pathway. In this study, we isolated and characterized two homologous BnaFAH genes in Brassica napus L. variant Westar, and then used CRISPR/Cas9-mediated targeted mutagenesis to generate a series of transgene-free mutant lines either with single or double-null bnafah alleles.
View Article and Find Full Text PDFRegen Ther
June 2024
Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Muscle Nerve
October 2024
Department of Neurology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Introduction/aims: Oculopharyngodistal myopathy type 4 (OPDM4) arises from a CGG repeat expansion in the 5' UTR of the RILPL1 gene. Reported cases of OPDM4 have been limited. The aim of this study was to investigate the clinical and myopathological characteristics of OPDM4 patients with advanced disease.
View Article and Find Full Text PDFGlycobiology
June 2024
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 Blvd LaSalle, H4H 1R3, Montreal, QC, Canada.
Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form a net-like coverings around certain neurons in the brain. PNNs are primarily composed of chondroitin sulfate (CS) proteoglycans from the lectican family that consist of CS-glycosaminoglycan side chains attached to a core protein. CS disaccharides can exist in various isoforms with different sulfation patterns.
View Article and Find Full Text PDFbioRxiv
June 2024
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Qc, Canada.
Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form a net-like coverings around certain neurons in the brain. PNNs are primarily composed of chondroitin sulfate (CS) proteoglycans from the lectican family that consist of CS-glycosaminoglycan (CS-GAG) side chains attached to a core protein. CS disaccharides can exist in various isoforms with different sulfation patterns.
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