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Single-Atom Cu Anchored on Carbon Nitride as a Bifunctional Glucose Oxidase and Peroxidase Nanozyme for Antibacterial Therapy.
ACS Nano
March 2025
Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
A very promising strategy to avoid bacterial drug resistance is to replace antibiotics with artificial nanozymes, but this has not yet been translated to the clinic. Here, we construct a single-atom nanozyme using graphitic carbon nitride nanosheets modified by copper (Cu--CN). This Cu--CN nanosheet possesses both glucose oxidase-like and peroxidase-like activities responsible for reactive-oxygen-species generation by a cascade reaction to eradicate Gram-positive and Gram-negative multidrug-resistant bacteria.
View Article and Find Full Text PDFShort bowel syndrome and d-lactic acidosis: A case report with supplemental home parenteral nutrition and teduglutide.
Endocrinol Diabetes Nutr (Engl Ed)
March 2025
Endocrinologia y Nutrición, Hospital Universitario de la Princesa, Calle Diego de León 62, 28007 Madrid, Spain.
d-Lactic acidosis is an uncommon cause of acidosis that occurs in patients with short bowel syndrome (SBS). Reduced intestinal absorption surface leads to carbohydrate malabsorption, fermented by abnormal colonic bacterial flora, resulting in elevated d-lactate levels. It should be suspected in SBS patients who exhibit typical neurological symptoms without other apparent causes, along with metabolic acidosis with normal l-lactate levels.
View Article and Find Full Text PDFAntibacterial mechanism of lysine against Escherichia coli O157:H7, its action on lettuce and in reducing the severity of murine colitis.
Food Microbiol
August 2025
College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China. Electronic address:
The aim of the present study was to evaluate the mechanism of antimicrobial action of Lysine (Lys) against Escherichia coli (E. coli) O157:H7. Lys alters the permeability and morphology of bacterial cell membranes, leading to leakage of intracellular material.
View Article and Find Full Text PDFDiabetic foot infections: Questions for an infectious disease consultant.
Semin Vasc Surg
March 2025
Division of Infectious Disease, Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.
Diabetic foot infection can lead to limb amputation in approximately 17% of affected patients. Given the complex pathophysiology associated with diabetic foot infection, the goal of limb preservation is best achieved with a multidisciplinary approach and a team of providers including infectious disease consultants. However, these infections often affect populations living in nonmetropolitan areas, where access to an infectious disease physician may be limited.
View Article and Find Full Text PDFTB dactylitis in a toddler.
BMJ Case Rep
March 2025
Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
A well-thriving male toddler presented with a painless swelling on the dorsal surface of his right hand, incidentally noticed by the mother. There was no history of local trauma or any systemic symptoms. On examination, there were no signs of inflammation over the swelling.
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