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[Determination of streptomycin and dihydrostreptomycin in grapes by liquid chromatography-tandem mass spectrometry].
Se Pu
December 2020
Institute of Quality and Standard of Agro-Products, Zhejiang Academy of Agricultural Sciences, State Key Laboratory for Managing Biotic and Chemical Theats to the Quality and Safety of Agro-Products, Hangzhou 310021, China.
Streptomycin (STR) and dihydrostreptomycin (DSTR) are two of the most common aminoglycoside antibiotics used in veterinary medicine. STR is produced by some strains, and DSTR is a derivative of STR. In recent years, STR has been widely used in grapes to induce denuclearization.
View Article and Find Full Text PDFTMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells.
Front Mol Neurosci
October 2017
Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoelectrical transducer (MET) channels present in their stereociliary bundles. There is strong evidence implying that transmembrane channel-like protein (TMC) 1 contributes to the pore-forming subunit of the mature MET channel, yet its expression is delayed (~>P5 in apical outer hair cells, OHCs) compared to the onset of mechanotransduction (~P1). Instead, the temporal expression of TMC2 coincides with this onset, indicating that it could be part of the immature MET channel.
View Article and Find Full Text PDFAminoglycoside ototoxicity: permeant drugs cause permanent hair cell loss.
J Physiol
September 2005
Neuroscience Center and Kresge Hearing Laboratories, Louisiana State University Health Sciences Center, New Orleans 70112, USA.
Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors.
J Pharmacol Exp Ther
October 1999
Lilly Research Laboratories, Neuroscience Discovery, Eli Lilly and Company, Indianapolis, Indiana, USA.
Recent pharmacological studies have led to the hypothesis that aminoglycoside-induced ototoxicity is an excitotoxic process mediated, at least in part, by a polyamine-like modulation of N-methyl-D-aspartate (NMDA) receptors. To explore this hypothesis, we compared the effects of several aminoglycosides (neomycin B, kanamycin A, streptomycin, and dihydrostreptomycin) with spermine on recombinant NMDA receptors of defined composition expressed in Xenopus oocytes. Like spermine, aminoglycosides potentiate agonist-induced responses in the presence of both saturating glycine ("glycine-independent") and subsaturating glycine ("glycine-dependent") concentrations on NR1A/2B receptors.
View Article and Find Full Text PDFOtotoxic antibiotics: a review.
Acta Otolaryngol Suppl
August 1995
Department of Otorhinolaryngology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Fifty years of experience with aminoglycoside antibiotics has confirmed their usefulness in many infections with Gram-negative bacteria. The ototoxic action has been investigated clinically in patients and in numerous animal studies. The increased knowledge about molecular structure, pharmacology and pharmacokinetics as well as information of the site of action in the labyrinth has resulted in reduced risks for severe toxic damage in kidneys and in the ear.
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