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Mouth Rinsing and Ingesting Unpleasant Salty or Bitter Solutions After Heavy-Intensity Cycling Does Not Influence Sprint Performance or Knee-Extensor Force in Trained Cyclists.
Int J Sports Physiol Perform
December 2024
School of Health Sciences, Western Sydney University, Campbelltown, NSW, Australia.
Purpose: The present study investigated the effect of unpleasant salty or bitter tastes on cycling sprint performance and knee-extensor force characteristics in different fatigue states.
Methods: Following a familiarization session, 11 trained male cyclists completed 3 experimental trials (salty, bitter, and water) in a randomized crossover order. In each trial, participants cycled at 85% of the respiratory compensation point for 45 minutes and then, after a 5-minute rest, completed a 1-minute sprint.
Dose-related effects of intraduodenal quinine on plasma glucose, glucoregulatory hormones and gastric emptying of a nutrient drink, and energy intake, in men with type 2 diabetes: a double-blind, randomised, crossover study.
Diabetologia
December 2024
Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Aims/hypothesis: Quinine, when administered intraduodenally to activate bitter-taste receptors, in a dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1) and insulin, slows gastric emptying and lowers postprandial glucose in healthy people, with consequent implications for the management of type 2 diabetes; the effect of quinine on energy intake is uncertain. We have investigated the dose-related effects of quinine on postprandial blood glucose levels and energy intake in people with type 2 diabetes.
Methods: Male participants with type 2 diabetes (age: 68±5 years; HbA: 49.
Highly multiplexed design of an allosteric transcription factor to sense new ligands.
Nat Commun
November 2024
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Article Synopsis
- * The study introduces Sensor-seq, a high-throughput platform that allows for the design and identification of aTF biosensors that can bind to a variety of non-native ligands, testing 17,737 variants of aTF TtgR against multiple compounds.
- * Sensor-seq successfully finds biosensors with high performance for various ligands and showcases their practical use through cell-free detection systems for specific drugs, enhancing the ability to create new biosensors beyond natural limitations.
A promising class of antiprotozoal agents, design and synthesis of novel Pyrimidine-Cinnamoyl hybrids.
Eur J Med Chem
January 2025
Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.
Malaria, caused by parasitic protozoans of the Plasmodium genus, continues to be one of the greatest global health crises, especially in Africa. The emergence of antimalarial drug resistance continues to be a health problem necessitating an urgent need for alternative and cost-effective antimalarials. Using a molecular hybridization approach, we report the design and synthesis of an efficacious novel class of antiprotozoal agents; (E)-1-(4-(4,6-diphenylpyrimidin-2-yl)piperazin-1-yl)-3-phenyl prop-2-en-1-one derivatives (8a-r).
View Article and Find Full Text PDFDesign, Synthesis, and Biological Evaluation of Novel Quinoline Derivatives against Phytopathogenic Bacteria Inspired from Natural Quinine Alkaloids.
J Agric Food Chem
October 2024
School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
A series of 2-(trifluoromethyl)-4-hydroxyquinoline derivatives were designed and synthesized with introduction of the antibacterial fragment amino alcohols, and their antibacterial activity against plant phytopathogenic bacteria was evaluated for the development of quinoline bactericides. It is worth noting that compound exhibited excellent antibacterial activity with a minimum inhibitory concentration (MIC) value of 3.12 μg/mL against ().
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