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Association of plasma metabolites with treatment response after intravitreal anti-vascular endothelial growth factor injections in treatment-naïve neovascular age-related macular degeneration.
BMJ Open Ophthalmol
March 2025
Ophthalmology, Mass Eye and Ear, Boston, Massachusetts, USA
Background/aims: To investigate the association between plasma metabolomic profiles and treatment response after intravitreal anti-vascular endothelial growth factor (VEGF) injections in treatment-naïve neovascular age-related macular degeneration (nAMD).
Methods: This is part of a prospective longitudinal study that included patients with treatment-naïve nAMD who have undergone three loading intravitreal anti-VEGF injections. All patients underwent ophthalmological examinations including spectral domain optical coherence tomography (SD OCT).
Identification of Two Immunoglobulin Light Chain Types and Expression of Immunoglobulin Diversity in Chinese Giant Salamander (Andrias davidianus).
Dev Comp Immunol
March 2025
College of Animal Science and Technology, Northwest A&F University Shaanxi,China. Electronic address:
Lacking research on immunoglobulins in the Chinese giant salamanders (Andrias davidianus) has left their populations vulnerable to pathogen infections, contributing to a sharp decline in their numbers. In this study, we employed the rapid amplification of cDNA ends (RACE) technique along with paired-end 300 bp read length (PE300) sequencing. This approach was used to construct a DNA library, which enabled us to investigate the diversity of immunoglobulin gene expression.
View Article and Find Full Text PDFSingle-center clinical efficacy analysis of 16 cases of primary light chain cardiac amyloidosis including stage IIIb patients.
Clin Exp Med
March 2025
Department of Hematology, The Affiliated Hospital of Hebei University, 212 Yuhua East Road, Baoding, 071000, Hebei, China.
Objective: To investigate the clinical efficacy of daratumumab versus bortezomib in patients with systemic light chain amyloidosis (pAL) with cardiac involvement, particularly those at stage IIIb.
Methods: Retrospective analysis of 16 AL patients with cardiac involvement, two groups of patients received treatment primarily with bortezomib and daratumumab, respectively. The hematologic remission rate, cardiac response rate, survival and adverse reactions of the two groups were analyzed.
Lower body mass index is associated with the achievement of target LDL in patients using PCSK9 inhibitors in Taiwan.
Eur J Med Res
March 2025
Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan, Taiwan.
Objective: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a standard therapy for patients who respond poorly to or cannot tolerate statins. However, identifying responders to PCSK9 inhibitors remains unclear. This study investigates the characteristics of patients who achieve target LDL-C reduction (< 70 mg/dl) after PCSK9 inhibitor therapy.
View Article and Find Full Text PDFMonitoring of immunoglobulin treatment compliance of patients with an inborn error of immunity during the pandemic period.
BMC Immunol
March 2025
Division of Pediatric Immunology, Bursa Uludag University Faculty of Medicine, Bursa, 16100, Turkey.
Background: During the coronavirus disease 2019 (COVID-19) pandemic, significant challenges have been encountered in managing patients with chronic diseases. This study aimed to evaluate the effects of the pandemic on follow-up and treatment adherence in patients receiving immunoglobulin replacement therapy (IRT).
Methods: A study examining the changes in IRT application methods was conducted between March 2020 and September 2021.
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