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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Background: Alzheimer's disease (AD) is a world-wide healthcare crisis among older adults. Sex, aging, and apolipoprotein E (APOE) genotype are among the most impactful risk factors for AD. Sleep is beneficial for memory and changes with age.
View Article and Find Full Text PDFManaging Intracranial Pressure Crisis.
Curr Neurol Neurosci Rep
December 2024
Division of Critical Care, Department of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.
Purpose Of Review: The objective of this review is to provide a comprehensive management protocol for the treatment of intracranial pressure (ICP) crises based on the latest evidence.
Recent Findings: The review discusses updated information on various aspects of critical care management in patients experiencing ICP crises, including mechanical ventilation, fluid therapy, hemoglobin targets, and hypertonic saline infusion, the advantages of ICP monitoring, the critical ICP threshold, and bedside neuromonitoring. All aspects of critical care treatment, including hemodynamic and respiratory support and adjustment of ICP reduction therapy, may impact patient outcomes.
Local field potential-based brain-machine interface to inhibit epileptic seizures by spinal cord electrical stimulation.
Biomed Phys Eng Express
November 2024
Edmond and Lily Safra International Institute of Neurosciences, Santos Dumont Institute, 59288-899 Macaiba, Brazil.
This study proposes a closed-loop brain-machine interface (BMI) based on spinal cord stimulation to inhibit epileptic seizures, applying a semi-supervised machine learning approach that learns from Local Field Potential (LFP) patterns acquired on the pre-ictal (preceding the seizure) condition.LFP epochs from the hippocampus and motor cortex are band-pass filtered from 1 to 13 Hz, to obtain the time-frequency representation using the continuous Wavelet transform, and successively calculate the phase lock values (PLV). As a novelty, the-score-based PLV normalization using both modified-means and Davies-Bouldin's measure for clustering is proposed here.
View Article and Find Full Text PDFArticle Synopsis
- In a study of patients with systemic sclerosis (SSc), researchers examined the safety of musculoskeletal corticosteroid (MSKC) injections, focusing on the risk of scleroderma renal crisis (SRC).
- Out of 136 SSc patients, 46 received a total of 330 MSKC injections with no significant changes in vital signs, kidney function, or other health markers observed before and after the injections.
- The study concluded that MSKC injections are generally safe for established SSc patients, with a very low risk of SRC, although monitoring is advised for individuals at higher risk or with recent-onset SSc.
Image-guided peripheral nerve interventions- applications and techniques.
Tech Vasc Interv Radiol
September 2024
Department of Radiology, Emory University, Atlanta, GA.
Interventional radiology continues to be at the forefront of acute and chronic pain management. Our unique imaging expertise and ability to target difficult to reach structures allows for the continuous development of new ways to treat a variety of pain generators. In addition, the advent of thermal ablation techniques and technologies has provided a unique opportunity to offer patients more durable and predictable options to treat their pain.
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