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CgLS mediates limonene synthesis of main essential oil component in secretory cavity cells of Citrus grandis 'Tomentosa' fruits.
Int J Biol Macromol
September 2024
Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Wushan Road, Guangzhou 510642, China; Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Natural Medicine, South China Agricultural University, Wushan Road, Guangzhou 510642, China; Guangdong Key Laboratory for Innovative Developmentand Utilization of Forest Plant Germplasm, South China Agricultural University, Wushan Road, Guangzhou 510642, China; Center for Medicinal Plants Research, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China. Electronic address:
d-Limonene is the predominant component of essential oil from Exocarpium Citri Grandis, known for its antibacterial, antioxidant, insecticidal, and anti-inflammatory properties. The synthesis, transport, and accumulation of d-limonene in Citrus grandis 'Tomentosa' fruits are regulated by limonene synthase (LS) and its associated regulatory genes. This study addresses the gap in understanding the spatiotemporal cytological changes of LS and its regulatory genes.
View Article and Find Full Text PDFPromotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells.
Int J Mol Sci
July 2024
Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
Osteoporotic vertebral compression fractures (OVCFs) are the most prevalent fractures among patients with osteoporosis, leading to severe pain, deformities, and even death. This study explored the use of ectopic embryonic calvaria derived mesenchymal stem cells (EE-cMSCs), which are known for their superior differentiation and proliferation capabilities, as a potential treatment for bone regeneration in OVCFs. We evaluated the impact of EE-cMSCs on osteoclastogenesis in a RAW264.
View Article and Find Full Text PDF3D human stem-cell-derived neuronal spheroids for neurotoxicity testing of methylglyoxal, highly reactive glycolysis byproduct and potent glycating agent.
Curr Res Toxicol
June 2024
Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Centre-National Toxicology Information Centre, Toxicology Unit, Pavia, Italy.
Article Synopsis
- The study investigates the cytotoxic effects of methylglyoxal (MGO) on human-derived 3D neuronal spheroids, a model that mimics human brain cells, particularly in relation to aging and neurodegenerative diseases.
- Results show that MGO leads to decreased cell viability and growth at low concentrations, with significant cellular damage observed at higher doses, including necrosis and apoptosis.
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Efficient intracellular drug delivery by co-administration of two antibodies against cell adhesion molecule 1.
J Control Release
July 2024
Department of Pathology, Faculty of Medicine, Kindai University, Osaka, Japan. Electronic address:
Cell adhesion molecule 1 (CADM1), a single-pass transmembrane protein, is involved in oncogenesis. We previously demonstrated the therapeutic efficacy of anti-CADM1 ectodomain monoclonal antibodies against mesothelioma; however, the underlying mechanism is unclear. In the present study, we explored the molecular behavior of anti-CADM1 antibodies in CADM1-expressing tumor cells.
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