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Pharmacogenetic Testing in Admixed Populations: Frequency of the AMR PGx Working Group Tier 1 Variant Alleles in Brazilians.
J Mol Diagn
January 2025
Clinical Research and Technological Development Division (Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico), Brazilian National Cancer Institute (Instituto Nacional de Câncer), Rio de Janeiro, Brazil. Electronic address:
This article examines the frequency distribution of Tier 1 pharmacogenetic variants of the Association for Molecular Pathology Pharmacogenomics Working Group Recommendations in two large (>1.000 individuals) cohorts of the admixed Brazilian population, and in patients from the Brazilian Public Health System enrolled in pharmacogenetic trials. Three Tier 1 variants, all in DPYD, were consistently absent, which may justify their non-inclusion in genotyping panels for Brazilians; 13 variants had frequency < 1.
View Article and Find Full Text PDFA shikimic acid derived carbon dots (SACNDs-FITC) for multi-modal detection and removal of Hg: Probe design, sensing performance, and applications in food analysis.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China.
The first shikimic acid derived fluorescent carbon dots (SACNDs-FITC) for multi-modal detection and simultaneous removal of Hg is revealed. The fluorescence of SACNDs-FITC centered at 520 nm can be selectively quenched by Hg, while the emission centered at 420 nm remains constant which can be used for self-calibration. Naked-eye distinguishable color change from yellow to colourless under daylight and from green to blue under UV light could be observed for SACNDs-FITC in the real-time detection of Hg.
View Article and Find Full Text PDFCRISPR-Cas12a-Mediated Growth of Gold Nanoparticles for DNA Detection in Agarose Gel.
ACS Sens
January 2025
Department of Clinical Laboratory of Sir Run Run Shaw Hospital, College of Biosystems Engineering and Food Science, Zhejiang University School of Medicine, Hangzhou 310058, People's Republic of China.
The rapid, simple, and sensitive detection of nucleic acid biomarkers plays a significant role in clinical diagnosis. Herein, we develop a label-free and point-of-care approach for isothermal DNA detection through the trans-cleavage activity of CRISPR-Cas12 and the growth of gold nanomaterials in agarose gel. The presence of the target can activate CRISPR-Cas12a to cleave single-stranded DNA, thus modulating the length and number of DNA sequences that mediate the growth of gold nanoparticles (AuNPs) or gold nanorods (AuNRs).
View Article and Find Full Text PDFHierarchical Nanocellulose Photonic Design for Synergistic Colored Radiative Cooling.
ACS Nano
January 2025
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China.
Daytime radiative cooling (DRC) materials offer a sustainable, pollution-free passive cooling solution. Traditional DRC materials are usually white to maximize solar reflectance, but applications like textiles and buildings need more aesthetic options. Unfortunately, colorizing DRC materials often reduce cooling efficiency due to colorant sunlight absorption.
View Article and Find Full Text PDFSonographic features of active Charcot neuro-osteoarthropathy: A case series.
Diabet Med
January 2025
School of Medicine, University of Galway, Galway, Ireland.
Aims: To describe the sonographic features of active Charcot neuro-osteoarthropathy (CNO) and assess the potential role of ultrasound in identifying those with active CNO.
Methods: Using a prospective case-series study design we assessed the sonographic features of 14 patients with a diagnosis of diabetes presenting with clinical signs and symptoms suspicious for active CNO. Patients had standard weight-bearing plain X-Ray and, where possible, MRI to evaluate the presence of active CNO.
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