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TRIB3 is a biomarker of poor prognosis in laryngeal squamous cell carcinoma and may affect tumor development through PI3K / AKT / mTOR pathway.
Clinics (Sao Paulo)
January 2025
Department of Otolaryngology and Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Anhui Province, China. Electronic address:
Objective: TRIB3 has been confirmed to participate in and regulate biological metabolic activities in head and neck tumors such as nasopharyngeal carcinoma and oropharyngeal carcinoma, so the purpose of this study was to explore whether there is a correlation between TRIB3 and Laryngeal Squamous Cell Carcinoma (LSCC) and to preliminarily explore the biological characteristics of TRIB3 in LSCC.
Methods: TRIB3 expression in the LSCC was analyzed based on The Cancer Genome Atlas (TCGA) database. CCK-8 assay, Colony Formation Assay, wound healing assay, and Transwell assay were performed to investigate the roles of TRIB3 in the proliferation, invasion and metastasis of LSCC.
Biomechanical and Functional Features of the Carrier Erythrocytes Prolonging Circulation Time of Biotherapeutic Targeted to Glycophorin A.
Bioconjug Chem
January 2025
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5127, United States.
Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the pharmacokinetics and pharmacodynamics of a protein cargo. Affinity targeting of Factor IX (FIX) to the RBC membrane is a promising approach to improve the (pro)enzyme's pharmacokinetics. For RBC targeting, purified human FIX was conjugated to the anti-mouse glycophorin A monoclonal antibody Ter119.
View Article and Find Full Text PDFDisease burden of influenza in Spain: A five-season study (2015-2020).
Hum Vaccin Immunother
December 2025
National Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Influenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospitalization, intensive care unit (ICU) admission and in-hospital mortality in Spain over five seasons (2015-2020) via publicly available Minimum Basic Datasets (MDBS).
View Article and Find Full Text PDFHow a responsive reproduction factor is determinant in a prey-predator dynamics: A numerical and analytical study in a discrete-time model.
Chaos
January 2025
Physics Institute, University of São Paulo, 05508-090 São Paulo, SP, Brazil.
In this work, we investigate the dynamics of a discrete-time prey-predator model considering a prey reproductive response as a function of the predation risk, with the prey population growth factor governed by two parameters. The system can evolve toward scenarios of mutual or only of predators extinction, or species coexistence. We analytically show all different types of equilibrium points depending on the ranges of growth parameters.
View Article and Find Full Text PDFAnalyzing the channels of information dissemination: Investigating abrupt transitions in resource investment.
Chaos
January 2025
Department of Applied Mathematics, College of Applied Sciences, Kyung Hee University, Yongin 17104, Republic of Korea.
Investment in resources is essential for facilitating information dissemination in real-world contexts, and comprehending the influence of resource allocation on information dissemination is, thus, crucial for the efficacy of collaborative networks. Nonetheless, current studies on information dissemination frequently fail to clarify the complex interplay between information distribution and resources in network contexts. In this work, we establish a resource-based information dissemination model to identify the complex interplay by examining the propagation threshold and equilibriums.
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