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| http://dx.doi.org/10.1097/00000658-196805000-00007 | DOI Listing |
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Orally administered boldine reduces muscle atrophy and promotes neuromuscular recovery in a rodent model of delayed nerve repair.
Front Cell Neurosci
September 2023
Department of Neurosurgery, Center for Brain Injury and Repair, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Peripheral nerve injury often results in poor functional recovery due to a prolonged period of muscle denervation. In particular, absent axonal contact, denervated muscle can undergo irrevocable atrophy and diminished receptiveness for reinnervation over time, ultimately reducing the likelihood for meaningful neuromuscular recovery. While innovative surgical approaches can minimize the harmful effects of denervation by re-routing neighboring-otherwise uninjured-axons, there are no clinically-available approaches to preserve the reinnervation capacity of denervated muscles.
View Article and Find Full Text PDFResorbable Nerve Wraps: Can They Be Overtightened?
J Reconstr Microsurg
November 2022
Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, New York.
Background: Nerve wrapping has been advocated to minimize scarring and adhesion following neurorrhaphy or neurolysis. A wrap should provide an enclosure that is snug enough to protect and support the affected nerve without strangulating the nerve. The degree to which resorbable wraps should be ": tightened" around the nerve is largely subjective with scant literature on the subject.
View Article and Find Full Text PDFThe Effects of a Porcine Extracellular Matrix Nerve Wrap as an Adjunct to Primary Epineurial Repair.
J Hand Surg Am
September 2021
Department of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:
Purpose: Outcomes after end-to-end epineural suture repair remain poor. Nerve wraps have been advocated to improve regeneration across repair sites by potentially reducing axonal escape and scar ingrowth; however, limited evidence currently exists to support their use.
Methods: Forty Lewis rats underwent median nerve division and immediate repair.
Scalpel edge roughness affects post-transection peripheral nerve regeneration.
Surg Open Sci
April 2021
Laboratory for Molecular Regeneration, Section of Plastic and Reconstructive Surgery, The University of Chicago, Chicago, IL 60637.
Background: Gentle and precise tissue dissection reduces collateral tissue damage and preserves its structural quality for optimizing healing. This is particularly true for peripheral nerve neurorrhaphy. Axon regeneration kinetics across the repair is dependent on the amount of intraneural fibrosis.
View Article and Find Full Text PDFRho-inhibition by local application of c3-toxin for enhancement of axonal sprouting in a rat end-to-side nerve repair model.
Microsurgery
March 2012
Department of Plastic and Hand Surgery, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg, Germany.
Introduction: The aim of the presented study was to investigate nerve regeneration after application of C3-Toxin, a Rho-GTPase inhibitor and to correlate morphometry, neurophysiology, and function in an end-to-side peroneal/tibial nerve repair model of the rat.
Materials And Methods: Twenty rats with a peroneal to tibial end-to-side neurorrhaphy were divided into two groups: 1) control group, 2) C3 fusion toxin group with intrafascicular application of 1 μg/100 μl C3 fusion toxin. Survival time was 8 weeks.
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