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Insights into Pneumocystis jirovecii pneumonia in South Africa (2018-2022).
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Department of Clinical Microbiology and Infectious Diseases, University of the Witwatersrand, Johannesburg, South Africa.
Pneumocystis jirovecii (P. jirovecii) causes P. jirovecii pneumonia (PJP) - a leading opportunistic infection among persons with advanced human immunodeficiency virus (HIV).
View Article and Find Full Text PDFInfection Screening and Vaccination of Adult and Pediatric Patients with Autoimmune Inflammatory Rheumatic Diseases: An Emirati Delphi Consensus.
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Department of Rheumatology, Dubai Hospital, Dubai Academic Health Corporation, Dubai, United Arab Emirate.
Introduction: Patients with autoimmune and inflammatory rheumatic diseases (AIIRD) have an increased susceptibility to infections due to their compromised immune systems and the use of immunosuppressive therapies. Infections are a leading cause of morbidity and mortality in these patients, emphasizing the need for strategies such as infection control and vaccination to prevent avoidable harm to both patients and healthcare workers. This study aims to provide expert consensus on infection screening and vaccination guidelines for AIIRD patients.
View Article and Find Full Text PDFBackground And Objective: Previously, the novel small molecule ISFP10 has been shown to inhibit fungal phosphoglucomutase (PGM) activity in and spp. With 50-fold selectivity over the human PGM molecule due to the presence of a unique yet conserved cysteine residue present in a number pathogenic fungal PGMs, use of this compound may provide a novel broad-spectrum approach to treating fungal infections. Accordingly, we sought to determine the tolerability in test animals receiving this compound, as well as the potential antifungal activity of ISFP10 on cultures of the common fungal pathogens and .
View Article and Find Full Text PDFThird-generation nanopore sequencing for rapid diagnosis of Pneumocystis jirovecii pneumonia and co-pathogens.
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Department of Tuberculosis, The Fourth People's Hospital of Nanning, Nanning, Guangxi 530023, China. Electronic address:
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