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Background: Preclinical investigations in Alzheimer's disease (AD) have highlighted the efficacy of gamma sensory stimulation in mitigating AD-related pathologies. Cognito Therapeutics, Inc. (Cambridge, MA) has designed the Sensory Stimulation System for safe at-home usage, to induce EEG-confirmed gamma oscillations as a potential treatment for AD.
View Article and Find Full Text PDFBackground: In the EEG research of Alzheimer's Disease (AD) and other diseases belonging to dementia, the literature is rapidly growing to indicate biomarkers specific to the type of dementia. The literature showed firm conclusions that decreasing event-related delta and theta responses could be a biomarker showing cognitive decline (Güntekin et al. 2022).
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia, but differentiating between them can be challenging due to overlapping symptoms [1]. Quantitative electroencephalography (EEG) is emerging as a promising tool to identify potential biosignatures that can distinguish AD and FTD [2]-[5]. Prior EEG research has revealed slowing of the posterior dominant rhythm (PDR) in both AD and FTD patients compared to controls, reflecting underlying neurodegeneration.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Assistance Publique Hopitaux de Paris (APHP), Paris, France.
Background: The identification of biomarkers for Alzheimer's disease (AD) remains a significant challenge, particularly for the clinical severity of the disease. Recent studies have shown that plasma brain-derived-tau (BD-Tau) could be a promising biomarker for the identification of AD-type neurodegeneration. This study aimed to investigate the potential of BD-Tau in differentiating various clinical stages of AD, ranging from cognitively unimpaired AD to severe dementia AD.
View Article and Find Full Text PDFBackground: Previous EEG studies highlighted the potential of analyzing neural oscillatory activity for differentially diagnosing Alzheimer's disease (AD) and frontotemporal dementia (FTD). We recently studied primary progressive aphasia (PPA) variants associated with AD and FTD, revealing distinctive patterns of alterations in linear lagged connectivity (LLC) values within the default mode network (DMN) and the salience network (SN). This study utilizes the same functional MRI-driven model for source reconstruction to investigate LLC values across typical amnestic AD and the behavioral variant of FTD (bvFTD).
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