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Neural underpinnings of a two-phase memory suppression process in the neural response to self-related and observed perspective views.
Int J Clin Health Psychol
October 2024
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Individuals often actively suppress intrusive memories to alleviate the distress they cause and maintain mental well-being. However, those with post-traumatic stress disorder (PTSD) often exhibit difficulties particularly in inhibiting or suppressing negative memories compared to individuals without PTSD. These memories can involve a physical threat either to the individual themselves or to others.
View Article and Find Full Text PDFPsychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review.
Epilepsia Open
December 2024
University of Florence, Florence, Italy.
People with epilepsy (PWE) are at higher risk of psychiatric disorders (PD), disability, and reduced quality of life than the general population, especially in childhood and adolescence and when seizures originate from the temporal lobe. Temporal Lobe Epilepsy (TLE) is the most common type of focal epilepsy and can be due to structural abnormalities, or non-lesional causes, such as genetic variants. The prevalence of PD is approximately 20%-30% in people with epilepsy in general, and from 40% up to 80% in people with TLE.
View Article and Find Full Text PDFCortical Functional Connectivity Changes in the Body-First and Brain-First Subtypes of Parkinson's Disease.
Mov Disord
November 2024
Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body-first subtype, where synucleinopathy originates from the peripheral autonomic nervous system. Conversely, in the brain-first subtype, pathology would arise in the brain.
View Article and Find Full Text PDFNeuropathic pain relief and altered brain networks after dorsal root entry zone microcoagulation in patients with spinal cord injury.
Brain Commun
November 2024
Spaulding Neuroimaging Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02129, USA.
Article Synopsis
- Spinal cord injury (SCI) below-level neuropathic pain is challenging to treat, but surgical lesions in the spinal cord’s dorsal root entry zone (DREZ) can target pain sources effectively.
- A study with eight patients showed significant improvement in pain relief after neuroelectrically guided DREZ microcoagulation surgery, with some experiencing long-term relief for over a year.
- Changes in brain connectivity were observed post-surgery, indicating that the procedure not only alleviated pain but also normalized brain function related to sensory and motor processing.
Distinguishing seizures in autoimmune limbic encephalitis from mesial temporal lobe epilepsy with hippocampal sclerosis: Clues of a temporal plus network.
J Neurol Sci
December 2024
Department of Human Neurosciences, 'Sapienza' University of Rome, 00185 Rome, Italy. Electronic address:
Objective: Diagnosing autoimmune limbic encephalitis (ALE) in adults with new-onset seizures can be challenging, especially when seizures represent the predominant manifestation and MRI findings are not straightforward. By comparison with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), this study aimed to identify ictal electro-clinical features that might help clinicians recognize ALE-related seizures.
Methods: This retrospective, multi-centre study analysed the ictal semiology and EEG correlate of 116 video-EEG-captured seizures in 40 ALE patients and 45 ones recorded in 21 MTLE-HS subjects.
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