Various sero-epidemiologic studies, including the preliminary report from Ibadan, have established that most women with premalignant and malignant carcinoma of the cervix have serologic evidence of infection of herpes type-2 virus. Using immunofluorescence method, the earlier report in Ibadan was confirmed, whereby the prevalence of HT-2 virus antibodies was shown to be significantly associated with carcinoma of the cervix, especially the squamous cell type. However, there was no such association with the grade and stage of the disease.
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