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Peripheral dopamine suppression and elevated cystatin C in early diabetic nephropathy in spontaneously diabetic rats.
Am J Physiol Renal Physiol
October 2024
Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Article Synopsis
- Intrarenal dopamine helps protect against diabetic nephropathy in early-stage diabetes by reducing glomerular hyperfiltration, oxidative stress, inflammation, and fibrosis in mice models.
- The study used benserazide to investigate the effects of peripheral dopamine on kidney function in spontaneously diabetic Torii rats, showing that lower peripheral dopamine levels worsen renal dysfunction.
- Findings reveal that peripheral dopamine plays a crucial role in controlling oxidative stress and kidney performance during the early stages of diabetic nephropathy, evidenced by its effect on markers of renal dysfunction.
Japanese Mucuna pruriens (Hasshou Beans) Showed Fast-acting and Long-lasting Effects in Parkinson's Disease.
Intern Med
October 2024
Department of Neurology, Wakayama Medical University, Japan.
Objective Mucuna pruriens (MP) is a legume whose seeds contain levodopa (LD), which has potential therapeutic effects against Parkinson's disease (PD). However, further research is needed to thoroughly evaluate its efficacy and safety for treating this condition. In this study, we analyzed the pharmacokinetics of MP grown in Japan and investigated its mechanism of action in PD.
View Article and Find Full Text PDFSperm utilize tumor necrosis factor alpha to shut down a 2-methoxyestradiol nongenomic pathway that accelerates oviductal egg transport in the rat.
Reproduction
April 2023
Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile.
In Brief: Mating shuts down the 2-methoxyestradiol (2ME) nongenomic pathway that accelerates oviductal egg transport in the rat. This study shows that sperm cells, but not vaginocervical stimulation, utilize TNF-α to shut down this 2ME nongenomic pathway.
Abstract: The transport of oocytes or embryos throughout the oviduct to the implantation site in the uterus is defined as egg transport.
Anti-cancer effect of entacaponeon esophageal cancer cells via apoptosis induction and cell cycle modulation.
Cancer Rep (Hoboken)
March 2023
Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Background: Esophageal cancer (EC) is the sixth leading cause of cancer-related death, despite many advances in treatment, the survival of patients still remains poor. In recent years, the N6-methyladenosine (m6A) has been introduced as one of the most important modifications at the epitranscriptome level, with an important role in the mRNA regulation in various diseases, such as cancers. The m6A is regulated by different factors, including FTO as a demethylase.
View Article and Find Full Text PDFCADMA-Chem: A Computational Protocol Based on Chemical Properties Aimed to Design Multifunctional Antioxidants.
Int J Mol Sci
October 2022
Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Av. Ferrocarril San Rafael Atlixco 186, Col. Leyes de Reforma 1A Sección, Mexico City 09310, Mexico.
A computational protocol aimed to design new antioxidants with versatile behavior is presented. It is called Computer-Assisted Design of Multifunctional Antioxidants and is based on chemical properties (CADMA-Chem). The desired multi-functionality consists of in different methods of antioxidant protection combined with neuroprotection, although the protocol can also be used to pursue other health benefits.
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