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Noninvasive Assessment of Liver Fibrosis in Patients With Iron Overload.
Ultrasound Med Biol
December 2024
Center for Ultrasound Research and Translation, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Objective: We assessed the diagnostic performance of ultrasound two-dimensional shear wave elastography (US 2D-SWE) to predict clinically significant fibrosis (CSF) in patients with serologic iron overload (SIO) and the subgroup with histologic liver iron overload (LIO).
Methods: A single-center retrospective cross-sectional study of adults with SIO (serum ferritin ≥ 200 ng/mL in females and ≥ 300 ng/mL in males) and suspected chronic liver disease with nonfocal liver biopsy results and US 2D-SWE exams within 1 year was performed. Histopathological fibrosis stage ≥2 and liver iron ≥2+ was considered CSF and LIO, respectively.
Role of radiation emergency medicine: historical view-a perspective on the past, present, and future.
J Radiat Res
December 2024
Faculty and Postgraduate School of Nursing, Tokyo Healthcare University, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8558, Japan.
The more science progresses, the more life and society change. Medicine also changes with the times and the culture. This is also true for radiation emergency medicine, which includes dose-assessment leading to diagnosis, treatment, medical follow-up and prognosis of persons who have developed acute injury or illness due to radioactive contamination or radiation exposure.
View Article and Find Full Text PDFDeep learning-based body composition analysis from whole-body magnetic resonance imaging to predict all-cause mortality in a large western population.
EBioMedicine
December 2024
Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:
Article Synopsis
- This study explores the use of advanced deep learning methods to automatically measure body composition from whole-body MRI scans, aiming to assess their ability to predict mortality in the general population.
- The investigation was based on data from two large Western European cohort studies, focusing on key body composition metrics such as subcutaneous and visceral adipose tissue, skeletal muscle, and intramuscular fat.
- Results indicate significant associations between several volumetric body composition measures and mortality risk, highlighting the potential of automated techniques to improve clinical outcomes related to cardiometabolic diseases and cancer.
Simultaneous determination of cytosolic aminoacyl-tRNA synthetase activities by LC-MS/MS.
Nucleic Acids Res
December 2024
Department Laboratory Medicine, Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.
In recent years, pathogenic variants in ARS genes, encoding aminoacyl-tRNA synthetases (aaRSs), have been associated with human disease. Patients harbouring pathogenic variants in ARS genes have clinical signs partly unique to certain aaRSs defects, partly overlapping between the different aaRSs defects. Diagnosis relies mostly on genetics and remains challenging, often requiring functional validation of new ARS variants.
View Article and Find Full Text PDFBiomarkers of systemic treatment response: MR images of intratumoral fat deposition in colorectal liver metastases (CRLM) after chemotherapy.
Int J Colorectal Dis
November 2024
Department of Clinical Radiology II, Faculty of Medicine, Medical University of Warsaw, 1A Stefan Banach St, 02-097, Warsaw, Poland.
Purpose: Colorectal cancer cells containing mobile lipids are said to be an early indicator of chemotherapy effects. The objective of the study was to examine the frequency and clinical relevance of intratumoral fat deposition in colorectal liver metastases (CRLM) post-chemotherapy using dual-echo chemical shift gradient-echo magnetic resonance imaging (MRI).
Methods: A retrospective analysis of 98 patients with CRLM diagnosed between 2017 and 2022 (69 M, mean age 62.
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