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Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of .
ACS Omega
July 2024
Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University, Fez 30 000, Morocco.
Anemia is a widespread global health concern necessitating effective, accessible, and natural interventions. The potential of medicinal plants to address anemia has garnered significant interest. Among these plants, parsley ( () L.
View Article and Find Full Text PDFMegalin-related mechanism of hemolysis-induced acute kidney injury and the therapeutic strategy.
J Pathol
July 2024
Department of Applied Molecular Medicine, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Article Synopsis
- - Hemolysis-induced acute kidney injury (AKI) results from damage to proximal tubule epithelial cells (PTECs) caused by heme and the formation of tubular casts; megalin, a receptor in PTECs, plays a key role in this process by facilitating the uptake of hemoglobin and heme-scavenging proteins.
- - Researchers studied the role of megalin in hemolysis-induced AKI using mice with targeted megalin knockout, discovering that megalin deficiency reduces the uptake of harmful proteins but increases tubular cast formation, indicating a complexity in protein reabsorption mechanisms.
- - The study explored cilastatin, a megalin blocker, as a potential therapy and found that it reduces
Accelerated atherosclerosis in beta-thalassemia.
Am J Physiol Heart Circ Physiol
November 2023
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Children with beta-thalassemia (BT) present with an increase in carotid intima-medial thickness, an early sign suggestive of premature atherosclerosis. However, it is unknown if there is a direct relationship between BT and atherosclerotic disease. To evaluate this, wild-type (WT, littermates) and BT (Hbb) mice, both male and female, were placed on a 3-mo high-fat diet with low-density lipoprotein receptor suppression via overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation (D377Y).
View Article and Find Full Text PDFSafety and feasibility of the gene transfer of hemopexin for conditions with increased free heme.
Exp Biol Med (Maywood)
July 2023
School of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil.
Heme is a fundamental molecule for several biological processes, but when released in the extracellular space such as in hemolytic diseases, it can be toxic to cells and tissues. Hemopexin (HPX) is a circulating protein responsible for removing free heme from the circulation, whose levels can be severely depleted in conditions such as sickle cell diseases. Accordingly, increasing HPX levels represents an attractive strategy to mitigate the deleterious effects of heme in these conditions.
View Article and Find Full Text PDFGenomic organization and gene evolution of two warm temperature acclimation proteins (Wap65s) of Micropterus salmoides and their responses to temperature and bacterial/viral infections.
Int J Biol Macromol
February 2023
Key Laboratory of Tropical and Subtropical Fisheries Resource Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Institute, Chinese Academy of Fishery Sciences, Guangzhou, China; Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Institute, Chinese Academy of Fishery Sciences, Guangzhou, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China. Electronic address:
Warm temperature acclimation-related 65-kDa proteins (Wap65s) are fish plasma acute-phase glycoproteins homologous to hemopexin with high affinity and clearance for heme. The study characterized Mswap65-1 and Mswap65-2 genes in Micropterus salmoides. Structural analysis showed MsWap65s contained conserved heme-binding sites.
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