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Maternal Exposure to Polystyrene Nanoplastics Disrupts Spermatogenesis in Mouse Offspring by Inducing Overexpression in Undifferentiated Spermatogonia.
ACS Nano
January 2025
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200241, China.
Undifferentiated spermatogonia (Undiff-SPG) plays a critical role in maintaining continual spermatogenesis. However, the toxic effects and molecular mechanisms of maternal exposure to nanoplastics on offspring Undiff-SPG remain elusive. Here, we utilized a multiomics combined cytomorphological approach to explore the reproductive toxicity and mechanisms of polystyrene nanoplastics (PS-NPs) on offspring Undiff-SPG in mice after maternal exposure.
View Article and Find Full Text PDFArticle Synopsis
- Thyroid and salivary gland cytopathology often present diagnostic challenges due to overlapping features and rare conditions, prompting a focused seminar at the 45th European Congress of Cytology to address these issues.
- The seminar showcased complex cases using fine-needle aspiration cytology (FNAC) alongside histopathological and molecular analyses to differentiate between benign and malignant lesions.
- The findings emphasize the necessity of a comprehensive, multidisciplinary diagnostic approach that integrates cytological, clinical, and histopathological data for accurate patient management.
Nuclear morphological characterisation of lobular carcinoma variants: a morphometric study.
Histopathology
December 2024
Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Background And Aims: Lobular carcinoma (LC) of the breast exhibits diverse morphology and clinical behaviour. The pleomorphic variant (pLC) displays distinct cytonuclear features and aggressiveness compared to the classic variant (cLC). However, diagnosing pLC remains subjective.
View Article and Find Full Text PDFPitfalls in Urine Cytology: A Case of Fumarate Hydratase-Deficient Renal Cell Carcinoma Initially Diagnosed as High-Grade Urothelial Carcinoma.
Diagn Cytopathol
January 2025
Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China.
Article Synopsis
- - A 33-year-old Asian woman diagnosed with a rare and aggressive form of renal cancer known as FH-deficient renal cell carcinoma (RCC) presented with hematuria and underwent imaging that showed a solid tumor and lymph node metastases.
- - Urinary cytology and subsequent tests indicated high-grade urothelial carcinoma, while a right nephrectomy revealed specific tumor characteristics and a lack of fumarate hydratase (FH) expression.
- - Genetic analysis confirmed a mutation in the FH gene, underscoring the necessity of combining cytological, histological, and genetic findings to accurately diagnose FH-deficient RCC.
Inside the Brain: Cerebrospinal Fluid Insights in Meningitis.
Cureus
August 2024
Pathology, Gandhi Medical College, Bhopal, IND.
Background Our study focused on meningitis, an infection that can spread through the bloodstream as a primary or secondary infection from other body parts, such as sinuses, ears, and lungs. It can affect patients who have experienced trauma or surgery, as well as those with congenital defects like spina bifida. Specifically, we examined bacterial, viral, and tuberculous meningitis (TBM) cases.
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