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Effect of isotonic sodium bicarbonate infusion on perioperative acid-base status among patients undergoing emergency laparotomy for perforation peritonitis (ISABEL trial): a randomized controlled trial.
Eur J Trauma Emerg Surg
January 2025
Department of Anaesthesia & Intensive Care, Postgraduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.
Purpose: Perioperative metabolic acidosis negatively affects patient outcomes. Perioperative fluid therapy has a clinically significant effect on acid-base balance. This study was conducted to evaluate the effects of isotonic sodium bicarbonate infusion (ISB) versus balanced crystalloid solution (BCS) on perioperative acid-base balance, in terms of postoperative base excess, among patients undergoing emergency laparotomy for perforation peritonitis.
View Article and Find Full Text PDFEffect of acetate- and lactate-containing intravenous fluid on acid-base status, electrolytes and plasma lactate concentration in dehydrated cats.
J Feline Med Surg
January 2025
LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU Munich, Munich, Germany.
Objectives: Acetate (ACE) and lactate (LAC)-containing balanced resuscitation fluids are commonly used for fluid therapy in cats. These fluids can influence acid-base and electrolyte status. This prospective randomised study compared two balanced crystalloid solutions regarding their effect on acid-base status, electrolytes and LAC concentrations in dehydrated cats after intravenous fluid therapy.
View Article and Find Full Text PDFEvaluation and Improving the Quality of Arterial Blood Gas Interpretation Among Junior Doctors in Aswan University Hospital: A Clinical Audit.
Cureus
December 2024
Pulmonary Medicine, Aswan University Hospitals, Aswan, EGY.
Article Synopsis
- Arterial blood gas (ABG) analysis is crucial for diagnosing critical conditions in patients, and misinterpretation can lead to serious management issues.
- A study conducted at Aswan University Hospitals involved 273 healthcare professionals and assessed their ABG interpretation skills before and after targeted educational interventions over two weeks.
- Results indicated significant improvements, with accuracy in interpreting ABG results increasing from 71.8% to 90.2% and enhanced skills in identifying acid-base disturbances and distinguishing between respiratory and metabolic issues.
Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid-Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial.
Drug Des Devel Ther
December 2024
Department of Anaesthesiology, Peking University People's Hospital, Peking, People's Republic of China.
Background: The 15° left tilt position during caesarean delivery has been recommended by guidelines for many years, but recent studies have questioned the clinical benefit of left tilt position. We hypothesize that using a higher starting dose of metaraminol in the supine position will result in a non-inferior umbilical arterial pH, compared to the 15° left tilt position.
Methods: Healthy women undergoing elective caesarean delivery were randomized to the supine position (n = 62) or 15° left tilt position (n = 62) after spinal anaesthesia (0.
Optimising risk stratification in diabetic ketoacidosis: a re-evaluation of acid-base status and hyperosmolarity using observational data.
Intern Emerg Med
December 2024
Department of Anaesthesia, Royal Darwin Hospital, Darwin, NT, 0810, Australia.
Accurate assessment of severity in diabetic ketoacidosis (DKA) can optimise early management and facilitate prioritisation for high acuity care. The primary aim was to evaluate the relationship between severity of acidosis (considering pH, bicarbonate, and anion gap) and hyperosmolarity with hospital mortality. Secondary outcomes included intensive care mortality, mechanical ventilation, vasopressor/inotrope use, and dialysis.
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