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Sudden sensorineural hearing loss (SSNHL) presents as the abrupt onset of hearing loss. Approximately 88% of SSNHL has no identifiable etiology and is termed idiopathic sudden sensorineural hearing loss (ISSHL). Hearing specialists have investigated ISSHL since the 1970s.
View Article and Find Full Text PDFQuantitative comparison of vascular characteristics of plus disease images published over time: International Classification of Retinopathy of Prematurity.
J AAPOS
December 2024
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina. Electronic address:
Plus disease was first defined in the original International Classification of retinopathy of prematurity (ICROP) publication in 1984. Over time, the definition of plus disease has evolved, and each ensuing ICROP publication has included example plus disease images. Because plus disease is often present when treatment is indicated, it is important to evaluate whether the retinal vascular characteristics (ie, dilation and tortuosity) depicted in these example images have remained the same or changed over time.
View Article and Find Full Text PDFSex differences in childhood cancer risk following ART conception: a registry-based study.
Hum Reprod
December 2024
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Study Question: Does the risk of childhood cancer following ARTs vary by sex?
Summary Answer: In this registry-based study, some childhood cancers showed positive sex- and age-specific associations in children conceived using certain ART modalities, which were not evident in overall combined analyses.
What Is Known Already: The relationship between ART and risk of childhood cancer has shown diverse outcomes in prior research. Studies examining whether there are sex differences in childhood cancer risk after ART conception are lacking.
Long-term outcome of pediatric acute severe colitis: A prospective 5-year follow-up of the PRASCO trial.
J Pediatr Gastroenterol Nutr
December 2024
Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Objectives: The PRASCO trial reported the short-term superiority of an antibiotic cocktail plus intravenous corticosteroids (IVCS) over IVCS alone in children with acute severe colitis (ASC). Here, we report the extension of the PRASCO trial and the long-term outcomes of the antibiotic cocktail in ASC.
Methods: This prospective follow-up of the PRASCO trial documented disease outcomes and treatments annually through 5 years.
Publication bias in studies on biologic therapy for children with inflammatory bowel disease.
J Pediatr Gastroenterol Nutr
December 2024
Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Objective: The utilization of biologic drugs in children with inflammatory bowel disease (IBD) surged following the publications of positive results in randomized controlled trials and real-world studies. We aimed to explore the extent of publication bias associated with these findings.
Methods: Two reviewers assessed all abstracts evaluating the efficacy or safety of biologics presented at the annual European Society for Pediatric Gastroenterology Hepatology and Nutrition and North American Society for Pediatric Gastroenterology conferences from 2015 to 2019.
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