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The combined effects of preservative chemicals in consumer products: An analysis using embryonic and adult zebrafish.
Chemosphere
June 2024
Department of Environmental Health, Graduate School at Yongin University, Yongin, 17092, Republic of Korea; Department of Occupational and Environmental Health, Yongin University, Yongin, 17092, Republic of Korea. Electronic address:
Benzisothiazolinone (BIT) and propyl paraben (PP) are preservatives in cleaning products; however, their toxicities are not well understood. In this study, zebrafish embryos were exposed to BIT, PP, and mixtures of both for 96 h to investigate the effects on growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the transcription of 19 genes related to the GH/IGFs axis. Concentrations of BIT and PP were measured in the whole body of larvae.
View Article and Find Full Text PDFThe Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods.
J Xenobiot
December 2023
Department of Medical Biophysics, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, 779 00 Olomouc, Czech Republic.
Triclosan and Triclocarban, preservatives widely used in cosmetics and other consumer products, underwent evaluation using a battery of new-approach methodologies in vitro (NAMs). Specifically, the Microplate Ames Test (MPF™ Test, Xenometrix, Allschwil, Switzerland) was employed to assess mutagenicity, the Comet assay in vitro on the HaCat cell line and the Mammalian Chromosome Aberration Test were utilized to evaluate genotoxicity, and the XenoScreen YES/YAS assay was applied to investigate endocrine disruption. The chemicals did not exhibit any positive responses for mutagenicity.
View Article and Find Full Text PDFNext step in the development of mesoprogestins: the preclinical profile of EC313.
Front Endocrinol (Lausanne)
September 2023
Evestra, Inc., Corporate Headquarters, Schertz, TX, United States.
Article Synopsis
- EC313 is a novel Selective Progesterone Receptor Modulator (SPRM) that exhibits both agonistic and antagonistic properties on the nuclear progesterone receptor, showing potential advantages over existing treatments.
- The estrogen-primed juvenile rabbit endometrium assay demonstrates that EC313 has stronger PR-agonistic effects than other mesoprogestins like Asoprisnil, indicating its effectiveness for conditions like uterine fibroids and endometriosis.
- In preclinical studies, EC313 effectively inhibits estrogenic activity and demonstrates superior anti-ovulatory effects without inducing premature labor, making it a promising candidate for further development in reproductive health treatments.
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project.
Front Toxicol
June 2023
Toxalim (Research Centre in Food Toxicology), Université de Toulouse, Institut National de Recherche Pour L'Agriculture, L'Alimentation et L'Environnement (INARE), Ecole Nationale Vétérinaire de Toulouse (ENVT), INP-Purpan, Université Paul Sabatier (UPS), Toulouse, France.
In past times, the analysis of endocrine disrupting properties of chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well as on aspects of steroidogenesis and the modulation of thyroid signaling. More recently, disruption of energy metabolism and related signaling pathways by exogenous substances, so-called metabolism-disrupting chemicals (MDCs) have come into focus. While general effects such as body and organ weight changes are routinely monitored in animal studies, there is a clear lack of mechanistic test systems to determine and characterize the metabolism-disrupting potential of chemicals.
View Article and Find Full Text PDFThe inhibition of steroid hormones determines the fate of IPC-366 tumor cells, highlighting the crucial role of androgen production in tumor processes.
Res Vet Sci
August 2023
Department Animal Physiology, Veterinary Medicine School, Complutense University of Madrid (UCM), 28040 Madrid, Spain. Electronic address:
Inflammatory mammary cancer (IMC) is a disease that affects female dogs. It is characterized by poor treatment options and no efficient targets. However, anti-androgenic and anti-estrogenic therapies could be effective because IMC has a great endocrine influence, affecting tumor progression.
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