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| http://dx.doi.org/10.1042/bj0920112 | DOI Listing |
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Investigation of the gastric digestion behavior of commercial infant formulae using an dynamic infant digestion model.
Front Nutr
December 2024
Riddet Institute, Massey University, Palmerston North, New Zealand.
The gastric digestion behavior of different commercial Stage 1 infant formulae (for 0-6 months) with different formulation backgrounds was investigated using an dynamic infant human gastric simulator (iHGS). The microstructural arrangements of the protein and lipid, colloidal stability and protein hydrolysis during digestion were elucidated. During gastric digestion, casein-dominant formulations showed a higher extent of aggregation due to their high proportion of casein micelles that underwent coagulation upon acidification and via the action of pepsin.
View Article and Find Full Text PDFPlatelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates.
Thromb Res
December 2024
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands. Electronic address:
Article Synopsis
- This study analyzes how different platelet collagen receptors (GPVI, α2β1, and GPIb-IX-V) interact with various sources of collagen, impacting platelet activation and thrombus formation.
- Ethical collagens tested include type I collagen from equine tendon, rat tail, and acid-soluble collagen from human umbilical cord.
- The results show varied reliance on receptors for platelet aggregation depending on the collagen type, with GPVI playing a crucial role in reducing thrombus parameters when inhibited, demonstrating that collective receptor interactions influence platelet behavior on different collagen surfaces.
Effect of protease hydrolysis on the structure of acidic heating-induced soy protein amyloid fibrils.
Int J Biol Macromol
December 2024
College of Food Science, Northeast Agricultural University, Harbin 150030, China. Electronic address:
The effectiveness of using amyloid fibrillation to improve the functional qualities of soy protein had drawn growing attention. However, the relationship between protein subunits and the structural polymorphism of soy protein-derived amyloid fibrils (SAFs) was not yet completely understood. In this study, soy protein subunits were hydrolyzed to different degrees according to the different action sites of different proteases (Pepsin, Papain and Alcalase).
View Article and Find Full Text PDFGlobal Transcriptomic Analysis of Topical Sodium Alginate Protection against Peptic Damage in an In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease.
Int J Mol Sci
October 2024
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Breakthrough symptoms are thought to occur in roughly half of all gastroesophageal reflux disease (GERD) patients despite maximal acid suppression (proton pump inhibitor, PPI) therapy. Topical alginates have recently been shown to enhance mucosal defense against acid-pepsin insult during GERD. We aimed to examine potential alginate protection of transcriptomic changes in a cell culture model of PPI-recalcitrant GERD.
View Article and Find Full Text PDFCharacterization, mechanisms, structure-activity relationships, and antihypertensive effects of ACE inhibitory peptides: rapid screening from sufu hydrolysate.
Food Funct
September 2024
Engineering Research Center of Active Substance and Biotechnology, Ministry of Education, College of Life Science, Chongqing Normal University, Chongqing 401331, China.
This study investigates the characterization, mechanisms of action, structure-activity relationships, and antihypertensive effects of ACE inhibitory peptides derived from sufu hydrolysate following simulated gastrointestinal digestion. Sufu was enzymatically digested using pepsin, trypsin, and chymotrypsin to mimic gastrointestinal conditions, followed by ultrafiltration to fractionate the peptides based on molecular weight. The fraction under 1 kDa exhibited the highest ACE inhibitory activity.
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