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Thyrotropin potentiation of insulin-like growth factor-I dependent deoxribonucleic acid synthesis in FRTL-5 cells: mediation by an autocrine amplification factor(s).
Endocrinology
February 1990
Department of Pediatrics, University of North Carolina, Chapel Hill 27599.
Studies were undertaken to determine the mechanism(s) by which TSH and insulin-like growth factors (IGFs) act synergistically to stimulate DNA synthesis in FRTL-5 cells. As observed in previous studies, the response of these cells to a combination of TSH plus IGFs (or micromolar concentrations of insulin) greatly surpass the sum of the effects of the individual hormones when acting alone. Part of this synergism was eliminated when media containing TSH and IGF-I were replaced every 4 h with fresh media.
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