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Polyethylene glycol loxenatide modulates lipid metabolism and insulin resistance through lncRNA steroid receptor RNA activator/cellular nucleic acid binding protein/Rho-associated coiled-coil kinase 2 axis in type 2 diabetes mellitus.
J Diabetes Investig
December 2024
Department of Endocrinology, Pingshan District People's Hospital of Shenzhen, Shenzhen, Guangdong Province, China.
Background: Polyethylene glycol loxenatide (PEG-Loxe) is applied in treating type 2 diabetes mellitus. Nevertheless, the effect and mechanism of PEG-Loxe on lipid metabolism disorder and insulin resistance in type 2 diabetes mellitus are not fully understood.
Methods: Type 2 diabetes mellitus rats developed by high-fat diet/streptozotocin injection were treated with PEG-Loxe (0.
The unique Pt(II)-induced nucleolar stress response and its deviation from DNA damage response pathways.
J Biol Chem
November 2024
Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA. Electronic address:
The mechanisms of action for the platinum compounds cisplatin and oxaliplatin have yet to be fully elucidated, despite the worldwide use of these drugs. Recent studies suggest that the two compounds may be working through different mechanisms, with cisplatin inducing cell death via the DNA damage response (DDR) and oxaliplatin utilizing a nucleolar stress-based cell death pathway. While cisplatin-induced DDR has been subject to much research, the mechanisms for oxaliplatin's influence on the nucleolus are not well understood.
View Article and Find Full Text PDFCircHIPK3 regulates cementoblast differentiation via the miR-10b-5p/DOHH/NF-κB axis.
Cell Signal
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Orthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:
Background: Intact cementum is vital for tooth stability and health. Cementoblasts, which line the root surface, are responsible for cementum formation. Recent evidence suggests that circular RNAs (circRNAs) are involved in various cellular functions and may have clinical applications.
View Article and Find Full Text PDFForce-enhanced sensitive and specific detection of DNA-intercalative agents directly from microorganisms at single-molecule level.
Nucleic Acids Res
October 2024
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Article Synopsis
- * The study introduces a new technique, the single-molecule stretching assay (SMSA), which can detect DNA-intercalating agents directly from small samples of microbial cultures without requiring extensive purification.
- * Using SMSA, researchers identified two strains that produce DNA intercalators and isolated three specific compounds, two of which (medermycin and kalafungin) showed promising anti-cancer effects against certain cancer cells.
siqRNA-seq is a spike-in-independent technique for quantitative mapping of mRNA landscape.
BMC Genomics
July 2024
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.
Background: RNA sequencing (RNA-seq) is widely used for gene expression profiling and quantification. Quantitative RNA sequencing usually requires cell counting and spike-in, which is not always applicable to many samples. Here, we present a novel quantitative RNA sequencing method independent of spike-ins or cell counting, named siqRNA-seq, which can be used to quantitatively profile gene expression by utilizing gDNA as an internal control.
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