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Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications.
Adv Healthc Mater
January 2025
Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use in inhalation therapies. The effectiveness of NO-based treatments relies on precise control of NO concentrations tailored to specific therapeutic needs. Electrochemical generation of NO (E-NOgen) via nitrite (NO ) reduction offers a scalable and efficient route for controlled NO production, while also addressing environmental concerns by reducing NO pollution and maintaining nitrogen cycle balance.
View Article and Find Full Text PDFRegional environmental impacts on growth traits and phytochemical profiles of Glycyrrhiza glabra L. for enhanced medicinal and industrial use.
BMC Plant Biol
January 2025
Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak, 38156-8-8349, Iran.
Identifying the optimal cultivation regions and evaluating the impact of environmental factors are crucial for selecting the best conditions for the commercial production of important medicinal and industrial plants. This study examined the effects of different cultivation areas-Rayen, Eghlid, Kalat, and Zanjan-on the agro-morphological and phytochemical traits of Glycyrrhiza glabra. The findings revealed that the location where the plants were grown significantly influenced their physical and chemical characteristics.
View Article and Find Full Text PDFInvestigating the factors contributing to the maintenance of high levels of warm season nocturnal ozone in a basin city.
Environ Pollut
January 2025
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China. Electronic address:
In recent years, ozone (O) pollution in many Chinese cities has worsened. Several cities have also experienced incidents where nocturnal O concentrations did not decrease as expected, and instead remained at high levels (above 50 ppb). However, there have been few detailed studies on the causes of these events.
View Article and Find Full Text PDFTrimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction.
Front Biosci (Landmark Ed)
January 2025
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, 401336 Chongqing, China.
Background: Myocardial ischemia-reperfusion (I/R) injury and coronary microcirculation dysfunction (CMD) are observed in patients with myocardial infarction after vascular recanalization. The antianginal drug trimetazidine has been demonstrated to exert a protective effect in myocardial ischemia-reperfusion injury.
Objectives: This study aimed to investigate the role of trimetazidine in endothelial cell dysfunction caused by myocardial I/R injury and thus improve coronary microcirculation.
Regulation of PHD2 by HIF-1α in Erythroid Cells: Insights into Erythropoiesis Under Hypoxia.
Int J Mol Sci
January 2025
Research Center for High Altitude Medicine, Qinghai University, Xining 810016, China.
The hypoxia-inducible factor (HIF) pathway has been demonstrated to play a pivotal role in the process of high-altitude adaptation. PHD2, a key regulator of the HIF pathway, has been found to be associated with erythropoiesis. However, the relationship between changes in Phd2 abundance and erythroid differentiation under hypoxic conditions remains to be elucidated.
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