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Analyzing the status of pre-hospital emergency medical services graduates in Iran during the last two decades.
J Educ Health Promot
November 2024
Department of Nursing, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Background: Pre-hospital emergency medical services (PHEMS) training system is an integral part of the health system of any country. Therefore, knowing the status of graduates of this field can provide a new analysis for the policymakers of the National Health System. The purpose of this study was to analyze the status of PHEMS graduates in Iran.
View Article and Find Full Text PDFIsoorientin: Unveiling the hidden flavonoid's promise in combating cancer development and progression - A comprehensive review.
Life Sci
January 2025
Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, Brazil; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, Brazil; Department of Biochemistry and Nutrition, School of Food and Technology of Marília (FATEC), Marília 17500-000, São Paulo, Brazil; UNIMAR Charity Hospital, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, Brazil.
Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell growth and the ability of tumors to invade surrounding tissues and spread to distant organs. Despite significant advancements in early detection, diagnosis, and treatment, many cancers still present substantial challenges due to their heterogeneity, resistance to conventional therapies, and severe side effects of existing treatments. Consequently, there is an ongoing need for novel therapeutic agents to selectively target cancer cells, enhance the efficacy of current treatments, and minimize adverse effects.
View Article and Find Full Text PDFFantastic Frogs and Where to Use Them: Unveiling the Hidden Cinobufagin's Promise in Combating Lung Cancer Development and Progression Through a Systematic Review of Preclinical Evidence.
Cancers (Basel)
November 2024
Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.
Article Synopsis
- Cinobufagin (CB) is a promising anticancer agent for lung cancer, showing potential through various preclinical studies that highlight its ability to inhibit tumor growth and promote cell death.
- The review analyzed data from both lab-based (in vitro) and animal (in vivo) studies, finding that CB decreases cell viability while affecting key molecular pathways related to cancer.
- Despite its effectiveness, limitations like the reliance on lab models, variability in study methodologies, and a lack of long-term safety data suggest more clinical trials are needed to confirm CB's safety and efficacy in humans.
The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review.
Pharmacol Res
November 2024
Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, São Paulo 17525-902, Brazil; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília, São Paulo 17525-902, Brazil; Department of Biochemistry and Nutrition, School of Food and Technology of Marília (FATEC), Marília, São Paulo 17500-000, Brazil; UNIMAR Charity Hospital, Universidade de Marília (UNIMAR), Marília, São Paulo 17525-902, Brazil.
The therapeutic potential of bee venom-derived peptides, particularly apamin and melittin, in cancer treatment has garnered significant attention as a promising avenue for advancing oncology. This systematic review examines preclinical studies highlighting the emerging role of these peptides in enhancing cancer therapies. Melittin and apamin, when conjugated with other therapeutic agents or formulated into novel delivery systems, have demonstrated improved efficacy in targeting tumor cells.
View Article and Find Full Text PDFThe identification of requirements for competency development during work-integrated learning in healthcare education.
BMC Med Educ
April 2024
Department of Movement and Sports Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, 9000, Belgium.
Background: Work-integrated learning (WIL) is widely accepted and necessary to attain the essential competencies healthcare students need at their future workplaces. Yet, competency-based education (CBE) remains complex. There often is a focus on daily practice during WIL.
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