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Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6.
Transl Psychiatry
January 2025
Research Center Juelich, Institute of Neuroscience and Medicine 10, Research Center Juelich, Juelich, Germany.
Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). rs16969968 is the primary Single Nucleotide Polymorphism (SNP) in CHRNA5 strongly associated with nicotine dependence and schizophrenia in humans. We performed single cell-electrophysiology combined with morphological reconstructions on layer 6 (L6) excitatory neurons in the medial PFC (mPFC) of wild type (WT) rats, rats carrying the human coding polymorphism rs16969968 in Chrna5 and α5 knockout (KO) rats.
View Article and Find Full Text PDFMeta-analysis of prospective longitudinal cohort studies on the impact of childhood traumas on anxiety disorders.
J Affect Disord
January 2025
Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Pudong New Area Mental Health Centre Affiliated to Tongji University, Shanghai 200124, China.
Objects: Childhood trauma is an early pathogenic factor that increases individuals' vulnerability to mental illness. This systematic review aims to explore the evidence regarding the association between childhood trauma and the subsequent occurrence of anxiety disorders.
Methods: Embase, Scopus, and PubMed databases were searched for peer-reviewed longitudinal cohort studies published in English between January 1, 1995, and November 15, 2022.
Analysis of radiation oncology integration within general practitioners' daily patient care: a cross-sectional survey in Germany.
Strahlenther Onkol
January 2025
Department of Radiation Oncology, Klinikum rechts der Isar, School of Medicine and Health, Technical, University of Munich (TUM), Ismaninger Str. 22, 81675, Munich, Germany.
Purpose: General practitioners (GPs) play a crucial role in providing interdisciplinary care for radiation oncology patients. This study aims to understand the specific needs and challenges faced by general practitioners in Germany when treating oncology patients.
Methods: A comprehensive web-based questionnaire with 24 items was disseminated to GPs in Germany via email using survio.
Altered brain dynamics of facial emotion processing in schizophrenia: a combined EEG/fMRI study.
Schizophrenia (Heidelb)
January 2025
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany.
Facial stimuli are relevant social cues for humans and essential signals for adequate social interaction. Impairments in face processing are well-documented in schizophrenia and linked to symptomatology, yet the underlying neural dynamics remain unclear. Here, we investigated the processing and underlying neural temporal dynamics of task-irrelevant emotional face stimuli using combined EEG/fMRI in 14 individuals with schizophrenia and 14 matched healthy controls.
View Article and Find Full Text PDFTiming of risk factors, prodromal features, and comorbidities of dementia from a large health claims case-control study.
Alzheimers Res Ther
January 2025
Department of Epidemiology and Healthcare Atlas, Central Research Institute of Ambulatory Health Care in Germany, Berlin, Germany.
Background: Many risk factors for dementia have been identified, but the timing of risk is less well understood. Here, we analyzed risk factors in a case-control study covering 10 years before an incident dementia diagnosis.
Methods: We designed a case-control study using insurance claims of outpatient consultations of patients with German statutory health insurance between January 1, 2012, and December 31, 2022.
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