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Atmospheric chemistry and environmental assessment of inhalational fluroxene.
Chemphyschem
November 2013
Faculty of Pharmacy, Physical Chemistry Department, University of Castilla La Mancha, Campus de Albacete, Edificio Polivalente, s/n, 02071 Albacete (Spain).
Smog chamber/gas chromatography techniques are used to investigate the atmospheric degradation of fluroxene, an anesthetic, through oxidation with OH and Cl radicals at 298 K and under atmospheric pressure of N2 or air. The measured rate constants (k) are: k(fluroxene+OH(.) )=(2.
View Article and Find Full Text PDFSynthesis of the fluorine-18 labeled inhalation anesthetics.
Appl Radiat Isot
November 1994
Department of Nuclear Medicine/PET, Kettering Memorial Hospital, Dayton, OH 45429.
Fourteen compounds (fluoroalkanes and fluoroethers), including the two most utilized inhalation anesthetics Isoflurane (CF3CHClOCF2H) and Halothane (CF3CHBrCl), have been labeled with fluorine-18 via a facile 18F-for-19F exchange reaction. The compounds include ten inhalation anesthetics which span a ten-fold range in potency and four structurally related non-anesthetics. All the compounds possess a trifluoromethyl group (CF3) adjoining a carbon atom with an acidic alpha-hydrogen and at least one halogen or a strong electron withdrawing group (X), [CF3CHXR].
View Article and Find Full Text PDFThe effect of two genes on anesthetic response in the nematode Caenorhabditis elegans.
Anesthesiology
August 1988
Department of Anesthesiology, Case Western Reserve University, University Hospitals, Cleveland, Ohio 44106.
The authors studied the wild type strain, N2, and three mutant strains of the nematode, Caenorhabditis elegans, in order to measure genetically produced changes in responses to nine volatile anesthetics. They determined the anesthetic ED50s of N2 for thiomethoxyflurane, methoxyflurane, chloroform, halothane, enflurane, isoflurane, fluroxene, flurothyl, and diethylether. The log-log relationship of the oil-gas partition coefficients (O/G) and the ED50s of these agents for N2 yields a straight line with a slope of -.
View Article and Find Full Text PDFStimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite.
Anesth Analg
November 1987
Department of Anesthesia, College of Medicine, University of Iowa, Iowa City 52242.
The structural similarity of the halothane metabolite, 2-chloro-1,1-difluoroethene (CDE), to haloethenes that are metabolized by and inactivate cytochrome P-450, suggests that CDE may undergo secondary metabolism and degrade these isozymes. This possibility was examined in hepatic microsomes by determining fluoride release and cytochrome P-450 loss due to CDE metabolism in the presence of several anesthetics. CDE alone decreased cytochrome P-450 from phenobarbital-treated rats by as much as 37%, but the addition of isoflurane or halothane to incubations containing CDE increased the loss of cytochrome P-450 nearly twofold.
View Article and Find Full Text PDF2,2,2-Trifluoroethanol-induced enteropathy in rats: chemically or bacterially mediated effects.
Toxicol Pathol
March 1988
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
The lethal effects of the fluorinated ether anesthetic, fluroxene, in rats are a consequence of its metabolism, which is catalyzed by cytochrome P-450 to the toxic metabolite 2,2,2-trifluoroethanol (TFE). The anesthetic or TFE (0.21 g/kg) caused decreased white blood cell counts, necrosis of bone marrow and lymphocytes, and decreased small intestine dry weight and was associated with septicemia.
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