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Understanding the effects of Bothrops erythromelas and Bothrops leucurus venoms on human blood coagulation.

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January 2025

Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brazil; Programa de Pós-Graduação Interunidades em Biotecnologia, São Paulo, Brazil; Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brazil. Electronic address:

Coagulation disorders are a primary symptom of envenomation caused by snakes belonging to the genus Bothrops. In the Northeast region of Brazil, the species Bothrops erythromelas and Bothrops leucurus are the main responsible for snakebite accidents. Due to the specific action of Bothrops venoms on several components of the coagulation cascade, the objective of this work was to characterize the coagulotoxic profile of B.

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Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for inducing thrombocytopenia in vivo. In previous studies, we showed that BjV incubated with metalloproteinase or serine proteinase inhibitors and/or anti-botrocetin antibodies still induced thrombocytopenia in rats and mice.

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Article Synopsis
  • Bothrops snake venom causes serious local effects like pain, swelling, and bleeding; it's made up mostly of metalloproteinases and phospholipase A2 toxins.
  • A study on 22 patients in Manaus highlighted common symptoms such as fang marks, infections, and blistering, along with specific skin changes like spongiosis and hyperkeratosis.
  • The findings suggest that both the venom and the body’s inflammatory response contribute to skin damage, indicating a need for improved treatment strategies for snakebite victims.
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Article Synopsis
  • Viperid snake venoms contain metalloproteinases like barnettlysin-III (Bar-III), which cause bleeding and disrupt blood clotting and tissue integrity in victims.
  • Bar-III, a specific type of metalloproteinase, has been characterized in terms of its properties, including its activity being enhanced by calcium and inhibited by zinc, and its ability to degrade important blood and tissue proteins.
  • The study also highlights Bar-III’s effects on platelets and endothelial cells, suggesting that it affects platelet aggregation and cell adhesion, providing insights that could lead to new treatments for snakebite envenomation.
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Ethnopharmacological Relevance: Hymenaea eriogyne Benth (Fabaceae) is popularly known as "Jatobá". Despite its use in folk medicine to treat inflammatory disorders, there are no descriptions that show its anti-inflammatory potential.

Aim Of The Study: In this sense, this study aimed to evaluate the anti-inflammatory and antivenom action of bark and leaves extract of H.

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