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Background: Flecainide and other class-Ic antiarrhythmic drugs (AADs) are widely used in Andersen-Tawil syndrome type 1 (ATS1) patients. However, class-Ic drugs might be proarrhythmic in some cases. We investigated the molecular mechanisms of class-I AADs proarrhythmia and whether they might increase the risk of death in ATS1 patients with structurally normal hearts.
View Article and Find Full Text PDFImpact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer's disease.
J Neuroinflammation
December 2024
Department of Neurosurgery, Stanford University School of Medicine, 1050 Arastradero Road, Building A, Palo Alto, Stanford, CA, 94304, United States of America.
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse models of Alzheimer's disease (AD). The current studies were designed to block noradrenergic signaling in 5XFAD mice through (1) chemogenetic inhibition of the locus coeruleus (LC), (2) pharmacologic blocking of β-adrenergic receptors, and (3) conditional deletion of β1- or β2-adrenergic receptors (adrb1 or adrb2) in microglia.
View Article and Find Full Text PDFCT-guided Left Stellate Ganglion Cryoneurolysis for Refractory Ventricular Arrhythmias.
Radiology
December 2024
From the Department of Radiology, Division of Interventional Radiology (N.L., N.J.R.), Department of Medicine, Division of Interventional Cardiology (Y.R.), and Department of Medicine, Division of Cardiovascular Medicine (Y.R., G.S., M.G.), UMass Memorial Medical Center and Chan Medical School, 55 Lake Ave N, S2-817A, Worcester, MA 01655; Department of Radiology and Imaging Sciences, Division of Interventional Radiology and Image-Guided Medicine, Emory University School of Medicine, Atlanta, Ga (J.K.); Division of Cardiology, Division of Electrophysiology, Emory Heart & Vascular Center at Saint Joseph's Hospital, Atlanta, Ga (A.M.P., C.M.T.); Department of Heart Failure/Transplant Cardiology, Piedmont Heart Institute, Piedmont Healthcare, Atlanta, Ga (D.W.M.); and Franklin College of Arts and Sciences, University of Georgia, Athens, Ga (F.J.P.).
Background Ventricular arrhythmias (VAs), including ventricular tachycardia and ventricular fibrillation, present substantial therapeutic challenges due to their high morbidity, mortality, and increasing prevalence. Current treatments often prove infeasible or inadequate in patients with refractory VAs. Purpose To evaluate the safety and effectiveness of CT-guided left stellate ganglion cryoneurolysis (SGC) in the treatment of refractory VAs.
View Article and Find Full Text PDFStress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer.
Mol Cancer Res
December 2024
University of California, Los Angeles, Los Angeles, CA, United States.
One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC). Chronic stress and obesity are recognized as risk factors for PDAC. We hypothesized that the combination of stress and obesity strongly promotes pancreatic cancer development and growth.
View Article and Find Full Text PDFRed blood cell signaling is functionally conserved in invasion.
iScience
October 2024
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Article Synopsis
- * Evidence shows that the invasion process involves manipulating RBC calcium signaling, particularly through the interaction between RH5 and basigin, which leads to increased cAMP and calcium influx in RBCs.
- * The research highlights a conserved signaling pathway in host RBCs critical for parasite invasion and suggests new targets for therapeutic interventions against merozoite invasion.
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