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Pulmonary infection caused by Tropheryma whipplei: a case report and review of the literature.
J Med Case Rep
December 2024
Jiangxi Medical Center for Critical Public Health Events, The First Affiliated Hospital of Nanchang University, Nanchang, 330052, Jiangxi, People's Republic of China.
Background: Tropheryma whipplei pneumonia is an infrequent medical condition. The clinical symptoms associated with this disease are nonspecific, often resulting in misdiagnosis or missed diagnosis. Therefore, sharing and summarizing the experiences in the diagnosis and treatment of this disease can deepen global understanding and awareness of it.
View Article and Find Full Text PDFA case of pneumonia caused by infection with Tropheryma whipplei complicated by cryptococcus during treatment with a Janus kinase inhibitor: a case report.
BMC Pulm Med
December 2024
Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, China.
This report describes the case of a 41-year-old male patient complaining of a hacking cough. The patient was treated with a Janus kinase (JAK) inhibitor for psoriasis. Blood tests revealed mild lymphopenia and high levels of serum cryptococcal antigen.
View Article and Find Full Text PDFPrimary actinomycotic osteomyelitis of metacarpal bones managed successfully with surgical debridement and Welsh regimen.
BMJ Case Rep
November 2024
Infectious Diseases, Kasturba Medical College Manipal, Manipal, Karnataka, India.
Mycetoma of the hand is a chronic granulomatous disease seen in the tropics and subtropical regions, mainly affecting the skin and subcutaneous tissue of the foot. Primary actinomycotic osteomyelitis involving the metacarpals is rarely reported in the literature. The conventional treatment for actinomycosis has been high-dose penicillin.
View Article and Find Full Text PDFRationale: Pulmonary sequestration (PS), a rare pulmonary disease, arises from congenital pulmonary vascular dysplasia. Meanwhile, pulmonary actinomycosis is a purulent infection of lung lesions triggered by the inhalation of actinomycetes, which is also uncommon. Even rarer is the occurrence of pulmonary actinomycete infection secondary to PS.
View Article and Find Full Text PDFPangenome analysis of five representative Tropheryma whipplei strains following multiepitope-based vaccine design via immunoinformatic approaches.
Mol Genet Genomics
October 2024
State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Article Synopsis
- Whipple disease, caused by the bacterium Tropheryma whipplei, affects multiple body systems, prompting the design of a multiepitope-based vaccine using proteomic data from five bacterial strains due to the absence of an approved vaccine.* -
- Researchers identified 829 core proteins shared among the strains and selected one important protein, WP_033800108.1, for vaccine development, which contains five promising immunodominant epitopes demonstrating strong binding affinity and immunogenicity.* -
- The resulting chimeric vaccine construct shows potential for inducing immune responses against various strains of T. whipplei and could serve as a foundation for future studies on vaccines targeting multi-strain pathogens.*
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