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Alzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Phenotyping Alzheimer's Disease (AD) can be crucial to providing personalized treatment. Several studies have analyzed the use of digital biomarkers to characterize a subject's behavior, usually obtained from a single modality, such as speech. However, combining several modalities in a single study has not been deeply studied.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Clinical rating scales and neuropsychological tests are commonly used for assessing sign and disease severity, yet lack detail in the early stages Alzheimer's Disease (AD). Existing evaluation methods can be subjective, nonlinear, expensive, or reliant on anecdotal evidence making objective and consistent characterization and phenotyping of AD difficult. Multimodal analysis of patient behavior, rather than scoring of patient-generated output which can be skewed by compensation strategies, presents a unique opportunity to objectively quantify AD related changes.
View Article and Find Full Text PDFActa Chir Orthop Traumatol Cech
January 2025
Department of Trauma and Orthopaedics, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK.
Purpose Of The Study: Lisfranc is a challenging injury both diagnostically and surgically, with sparse long-term literature evidence of surgical practice. We aim to review our long-term specialist orthopaedic institutional experience of Lisfranc injuries and the surgical management of this complex injury, specifically considering surgical outcomes as per radiological and clinical assessment.
Material And Methods: We present data from a prospectively maintained institutional database, reviewing patients who underwent operative fixation for Lisfranc injury between April 2014 and August 2020.
Acta Chir Orthop Traumatol Cech
January 2025
Neurochirurgická klinika Fakultní nemocnice Olomouc.
Purpose Of The Study: The annual number of spinal fusion procedures has been increasing and is well documented worldwide. The O-arm is slowly becoming the standard for transpedicular screw insertion. The accuracy and safety of this method have been confirmed by many studies.
View Article and Find Full Text PDFPurpose Of The Study: Intraarticular fractures of the distal femur rank among the most severe musculoskeletal injuries. Various treatment options, such as plate osteosynthesis or retrograde nailing, can be employed. This study aims to evaluate the clinical outcomes and complications of intraarticular distal femoral fractures treated with retrograde femoral nail, with particular emphasis on C3 fractures.
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